A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Irradiations
2.2. In Vivo Experiment
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Grade 1, Minimal | This corresponds to a histopathologic change ranging from inconspicuous to barely noticeable but so minor, small, or infrequent as to warrant no more than the least assignable grade. For multifocal or diffusely distributed lesions, this grade was used for processes where less than approximately 10% of the tissue in an average high-power field was involved. |
Grade 2, Slight | This corresponds to a histopathologic change that is a noticeable but not a prominent feature of the tissue. For multifocal or diffusely distributed lesions, this grade was used for processes where between approximately 10% and 25% of the tissue in an average high-power field was involved. |
Grade 3, Moderate | This corresponds to a histopathologic change that is a prominent but not a dominant feature of the tissue. For multifocal or diffusely distributed lesions, this grade was used for processes where between approximately 25% and 50% of the tissue in an average high-power field was involved. |
Grade 4, Marked | This corresponds to a histopathologic change that is a dominant but not an overwhelming feature of the tissue. For multifocal or diffusely distributed lesions, this grade was used for processes where between approximately 50% and 95% of the tissue in an average high-power field was involved. |
Grade 5, Severe | This corresponds to a histopathologic change that is an overwhelming feature of the tissue. For multifocal or diffusely distributed lesions, this grade was used for processes where greater than approximately 95% of the tissue in an average high-power field was involved. |
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Score | Observation |
---|---|
Normal | 0 |
Erythema | 1 |
Dry desquamation | 2 |
Moist desquamation | 3 |
Ulceration | 4 |
Necrosis | 5 |
GROUP | Epidermal Hyperplasia | Epidermal Necrosis | Inflammation Infiltration | Dermal Edema | Decrease in Annexa |
---|---|---|---|---|---|
Control | 0.3 ± 0.5 | 0.0 | 0.0 | 0.0 | 0.0 |
MBRT | 1.0 ± 0.5 | 0.0 | 0.5 ± 0.5 | 0.0 | 0.5 ± 0.5 |
BB | 1.3 ± 0.7 | 2.8 ± 1.0 | 3.3 ± 0.9 | 2.6 ± 1.2 | 2.3 ± 0.8 |
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Prezado, Y.; Hirayama, R.; Matsufuji, N.; Inaniwa, T.; Martínez-Rovira, I.; Seksek, O.; Bertho, A.; Koike, S.; Labiod, D.; Pouzoulet, F.; et al. A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy. Cancers 2021, 13, 1356. https://doi.org/10.3390/cancers13061356
Prezado Y, Hirayama R, Matsufuji N, Inaniwa T, Martínez-Rovira I, Seksek O, Bertho A, Koike S, Labiod D, Pouzoulet F, et al. A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy. Cancers. 2021; 13(6):1356. https://doi.org/10.3390/cancers13061356
Chicago/Turabian StylePrezado, Yolanda, Ryochi Hirayama, Naruhiro Matsufuji, Taku Inaniwa, Immaculada Martínez-Rovira, Olivier Seksek, Annaïg Bertho, Sachiko Koike, Dalila Labiod, Frederic Pouzoulet, and et al. 2021. "A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy" Cancers 13, no. 6: 1356. https://doi.org/10.3390/cancers13061356