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Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

1
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
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Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
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Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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Department of Microbiology, Soochow University, Taipei 111, Taiwan
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Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan
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Center for Cancer Research, Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan
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School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
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Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
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Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan
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National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Lang Wu
Cancers 2021, 13(12), 2978; https://doi.org/10.3390/cancers13122978
Received: 15 May 2021 / Revised: 10 June 2021 / Accepted: 12 June 2021 / Published: 14 June 2021
(This article belongs to the Special Issue Molecular Biomarkers for Risk and Prognosis of Cancer)
Breast cancer emergencies have become a rapidly evolving field in medicine during the last ten years. Carcinogenesis is a multiparametric process that involves diverse factors such as genetic, environmental, or aging. Recent research that elucidates the tumor biology and molecular pathways that mediate cancer progression and drug resistance has led to the development of various molecular targeted therapies involving monoclonal antibodies, small molecule receptor tyrosine kinase inhibitors, and agents that block downstream signaling pathways in breast cancer.
Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies. View Full-Text
Keywords: breast cancer; target therapy; biomarkers; pathogenesis breast cancer; target therapy; biomarkers; pathogenesis
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MDPI and ACS Style

Li, C.-J.; Tzeng, Y.-D.T.; Chiu, Y.-H.; Lin, H.-Y.; Hou, M.-F.; Chu, P.-Y. Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer. Cancers 2021, 13, 2978. https://doi.org/10.3390/cancers13122978

AMA Style

Li C-J, Tzeng Y-DT, Chiu Y-H, Lin H-Y, Hou M-F, Chu P-Y. Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer. Cancers. 2021; 13(12):2978. https://doi.org/10.3390/cancers13122978

Chicago/Turabian Style

Li, Chia-Jung, Yen-Dun T. Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, and Pei-Yi Chu. 2021. "Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer" Cancers 13, no. 12: 2978. https://doi.org/10.3390/cancers13122978

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