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Altered Organelle Calcium Transport in Ovarian Physiology and Cancer

1
Department of Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania
3
Center for Advanced Laser Technologies (CETAL), National Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 77125 Măgurele, Romania
4
Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), 91-95 Splaiul Independenţei, 050095 Bucharest, Romania
5
Alessandrescu-Rusescu National Institute of Mother and Child Health, Fetal Medicine Excellence Research Center, 020395 Bucharest, Romania
6
Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
7
Department of Surgical Oncology, Prof. Dr. Alexandru Trestioreanu Oncology Institute, Carol Davila University of Medicine and Pharmacy, 252 Fundeni Rd., 022328 Bucharest, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(8), 2232; https://doi.org/10.3390/cancers12082232
Received: 5 July 2020 / Revised: 31 July 2020 / Accepted: 6 August 2020 / Published: 10 August 2020
(This article belongs to the Special Issue Targeting Calcium Signaling in Cancer Cells)
Calcium levels have a huge impact on the physiology of the female reproductive system, in particular, of the ovaries. Cytosolic calcium levels are influenced by regulatory proteins (i.e., ion channels and pumps) localized in the plasmalemma and/or in the endomembranes of membrane-bound organelles. Imbalances between plasma membrane and organelle-based mechanisms for calcium regulation in different ovarian cell subtypes are contributing to ovarian pathologies, including ovarian cancer. In this review, we focused our attention on altered calcium transport and its role as a contributor to tumor progression in ovarian cancer. The most important proteins described as contributing to ovarian cancer progression are inositol trisphosphate receptors, ryanodine receptors, transient receptor potential channels, calcium ATPases, hormone receptors, G-protein-coupled receptors, and/or mitochondrial calcium uniporters. The involvement of mitochondrial and/or endoplasmic reticulum calcium imbalance in the development of resistance to chemotherapeutic drugs in ovarian cancer is also discussed, since Ca2+ channels and/or pumps are nowadays regarded as potential therapeutic targets and are even correlated with prognosis. View Full-Text
Keywords: ovarian cancer; organelles; calcium signaling; drug resistance ovarian cancer; organelles; calcium signaling; drug resistance
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MDPI and ACS Style

Caravia, L.; Staicu, C.E.; Radu, B.M.; Condrat, C.E.; Crețoiu, D.; Bacalbașa, N.; Suciu, N.; Crețoiu, S.M.; Voinea, S.C. Altered Organelle Calcium Transport in Ovarian Physiology and Cancer. Cancers 2020, 12, 2232. https://doi.org/10.3390/cancers12082232

AMA Style

Caravia L, Staicu CE, Radu BM, Condrat CE, Crețoiu D, Bacalbașa N, Suciu N, Crețoiu SM, Voinea SC. Altered Organelle Calcium Transport in Ovarian Physiology and Cancer. Cancers. 2020; 12(8):2232. https://doi.org/10.3390/cancers12082232

Chicago/Turabian Style

Caravia, Laura, Cristina E. Staicu, Beatrice M. Radu, Carmen E. Condrat, Dragoș Crețoiu, Nicolae Bacalbașa, Nicolae Suciu, Sanda M. Crețoiu, and Silviu C. Voinea 2020. "Altered Organelle Calcium Transport in Ovarian Physiology and Cancer" Cancers 12, no. 8: 2232. https://doi.org/10.3390/cancers12082232

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