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Cancers
Volume 12
Issue 8
10.3390/cancers12082001
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Review

Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives

by
Reetu Mukherji
1,
John L. Marshall
1,* and
Andreas Seeber
2
1
Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
2
Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck A-6020, Austria
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(8), 2001; https://doi.org/10.3390/cancers12082001
Submission received: 1 July 2020 / Revised: 17 July 2020 / Accepted: 18 July 2020 / Published: 22 July 2020
(This article belongs to the Special Issue Adjuvant Chemotherapy for Colorectal Cancer)
Versions Notes

Abstract

The selection of treatment according to genomic alterations is a standard approach in metastatic colorectal cancer but is only starting to have an impact in the earlier stages of the disease. The status of genes like KRAS, BRAF, and MMR has substantial survival implications, and concerted research efforts have revolutionized treatment towards precision oncology. In contrast, a genomic-based approach has not changed the adjuvant setting after curative tumor-resection in the daily routine so far. This review focuses on the current knowledge regarding prognostic and predictive genomic biomarkers in patients with locally advanced nonmetastasized colorectal cancer. Furthermore, we provide an outlook on future challenges for a personalized adjuvant treatment approach in patients with colorectal cancer.
Keywords: colorectal cancer; adjuvant; chemotherapy; microsatellite instability; genomic; prognosis colorectal cancer; adjuvant; chemotherapy; microsatellite instability; genomic; prognosis

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MDPI and ACS Style

Mukherji, R.; Marshall, J.L.; Seeber, A. Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives. Cancers 2020, 12, 2001. https://doi.org/10.3390/cancers12082001

AMA Style

Mukherji R, Marshall JL, Seeber A. Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives. Cancers. 2020; 12(8):2001. https://doi.org/10.3390/cancers12082001

Chicago/Turabian Style

Mukherji, Reetu, John L. Marshall, and Andreas Seeber. 2020. "Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives" Cancers 12, no. 8: 2001. https://doi.org/10.3390/cancers12082001

APA Style

Mukherji, R., Marshall, J. L., & Seeber, A. (2020). Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives. Cancers, 12(8), 2001. https://doi.org/10.3390/cancers12082001

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