Relevance of Regulatory T Cells during Colorectal Cancer Development
Abstract
:1. Introduction
2. Regulatory T Cells: Brief Summary
3. Treg Cells during CRC in Clinical Cases: An Overview
4. Treg Cells during CRC in Murine Models
5. Subpopulations of Treg Cells during CRC
6. Immune Molecules and Cells Promoting or Inhibiting Treg Cell Activity during CRC
6.1. TGF-β1, Runt-Related Transcription Factor (RUNX) 3, and GARP
6.2. IL-33 Receptor
6.3. Vascular Endothelial Growth Factor (VEGF)
6.4. Indoleamine 2,3-Dioxygenase (IDO)
6.5. CD39
6.6. Tumor-Associated Macrophages (TAMs)
6.7. Natural Killer (NK) Cells
6.8. Invariant NK T Cells (iNKT Cells)
7. Are Treg Cells a Good Target for Immunotherapy during CRC?
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Olguín, J.E.; Medina-Andrade, I.; Rodríguez, T.; Rodríguez-Sosa, M.; Terrazas, L.I. Relevance of Regulatory T Cells during Colorectal Cancer Development. Cancers 2020, 12, 1888. https://doi.org/10.3390/cancers12071888
Olguín JE, Medina-Andrade I, Rodríguez T, Rodríguez-Sosa M, Terrazas LI. Relevance of Regulatory T Cells during Colorectal Cancer Development. Cancers. 2020; 12(7):1888. https://doi.org/10.3390/cancers12071888
Chicago/Turabian StyleOlguín, Jonadab E., Itzel Medina-Andrade, Tonathiu Rodríguez, Miriam Rodríguez-Sosa, and Luis I. Terrazas. 2020. "Relevance of Regulatory T Cells during Colorectal Cancer Development" Cancers 12, no. 7: 1888. https://doi.org/10.3390/cancers12071888