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Volume 12
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Review

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

by
Manuela Porru
1,†,
Pasquale Zizza
2,†,
Nadia Panera
3,
Anna Alisi
3,
Annamaria Biroccio
2,* and
Carlo Leonetti
1,*
1
UOSD SAFU, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCSS-Regina Elena National Cancer Institute, 00144 Rome, Italy
2
UOSD Oncogenomic and Epigenetic Unit, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCSS-Regina Elena National Cancer Institute, 00144 Rome, Italy
3
Research Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
*
Authors to whom correspondence should be addressed.
†
Equally contributors.
Cancers 2020, 12(7), 1830; https://doi.org/10.3390/cancers12071830
Submission received: 1 June 2020 / Revised: 3 July 2020 / Accepted: 6 July 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Metastatic Colorectal Cancer)
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Abstract

Metastatic colorectal cancer (mCRC) remains challenging because of the emergence of resistance mechanisms to anti-epidermal growth factor receptor (EGFR) therapeutics, so more effective strategies to improve the patients’ outcome are needed. During the last decade, the application of a multi-omics approach has contributed to a deeper understanding of the complex molecular landscape of human CRC, identifying a plethora of drug targets for precision medicine. Target validation relies on the use of experimental models that would retain the molecular and clinical features of human colorectal cancer, thus mirroring the clinical characteristics of patients. In particular, organoids and patient-derived-xenografts (PDXs), as well as genetically engineered mouse models (GEMMs) and patient-derived orthotopic xenografts (PDOXs), should be considered for translational purposes. Overall, omics and advanced mouse models of cancer represent a portfolio of sophisticated biological tools that, if optimized for use in concert with accurate data analysis, could accelerate the anticancer discovery process and provide new weapons against cancer. In this review, we highlight success reached following the integration of omics and experimental models; moreover, results produced by our group in the field of mCRC are also presented.
Keywords: colon cancer; anti-EGF; new therapies; organoids; PDXs; orthotopic tumors; GEMM; omics technologies colon cancer; anti-EGF; new therapies; organoids; PDXs; orthotopic tumors; GEMM; omics technologies

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MDPI and ACS Style

Porru, M.; Zizza, P.; Panera, N.; Alisi, A.; Biroccio, A.; Leonetti, C. Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer. Cancers 2020, 12, 1830. https://doi.org/10.3390/cancers12071830

AMA Style

Porru M, Zizza P, Panera N, Alisi A, Biroccio A, Leonetti C. Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer. Cancers. 2020; 12(7):1830. https://doi.org/10.3390/cancers12071830

Chicago/Turabian Style

Porru, Manuela, Pasquale Zizza, Nadia Panera, Anna Alisi, Annamaria Biroccio, and Carlo Leonetti. 2020. "Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer" Cancers 12, no. 7: 1830. https://doi.org/10.3390/cancers12071830

APA Style

Porru, M., Zizza, P., Panera, N., Alisi, A., Biroccio, A., & Leonetti, C. (2020). Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer. Cancers, 12(7), 1830. https://doi.org/10.3390/cancers12071830

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