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Open AccessReview

Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion

1
Laboratory of Advanced Translational Research, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy
2
General Surgery Unit, Azienda Ospedaliera di Padova, 35128 Padua, Italy
3
Department of Molecular Medicine DMM, University of Padua, 35121 Padua, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1748; https://doi.org/10.3390/cancers12071748
Received: 8 June 2020 / Revised: 26 June 2020 / Accepted: 28 June 2020 / Published: 1 July 2020
The immune system is a crucial regulator of tumor biology with the capacity to support or inhibit cancer development, growth, invasion and metastasis. Emerging evidence show that reactive oxygen species (ROS) are not only mediators of oxidative stress but also players of immune regulation in tumor development. This review intends to discuss the mechanism by which ROS can affect the anti-tumor immune response, with particular emphasis on their role on cancer antigenicity, immunogenicity and shaping of the tumor immune microenvironment. Given the complex role that ROS play in the dynamics of cancer-immune cell interaction, further investigation is needed for the development of effective strategies combining ROS manipulation and immunotherapies for cancer treatment. View Full-Text
Keywords: reactive oxygen species; oxidative stress; immunity; inflammation; cancer reactive oxygen species; oxidative stress; immunity; inflammation; cancer
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MDPI and ACS Style

Kotsafti, A.; Scarpa, M.; Castagliuolo, I.; Scarpa, M. Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion. Cancers 2020, 12, 1748.

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