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Article

Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand

1
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
2
Institute of Oral Medicine and Department of Stomatology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70101, Taiwan
3
Center of Applied Nanomedicine, National Cheng Kung University, Tainan 70101, Taiwan
4
Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada
5
Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
6
Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 70101, Taiwan
*
Author to whom correspondence should be addressed.
Equal contribution.
Cancers 2020, 12(6), 1569; https://doi.org/10.3390/cancers12061569
Received: 11 May 2020 / Revised: 7 June 2020 / Accepted: 9 June 2020 / Published: 13 June 2020
(This article belongs to the Collection Cancer Biomarkers)
Head and neck cancer (HNC) accounts for more than 330,000 cancer deaths annually worldwide. Despite late diagnosis being a major factor contributing to HNC mortality, no satisfactory biomarkers exist for early disease detection. Cytoplasmic gelsolin (cGSN) was discovered to predict disease progression in HNC and other malignancies, and circulating plasma gelsolin (pGSN) levels are significantly correlated with infectious and inflammatory disease prognoses. Here, the plasma levels of five candidate biomarkers (circulating pGSN, squamous cell carcinoma antigen, cytokeratin 19 fragment, soluble Fas, and soluble Fas ligand (sFasL)) in 202 patients with HNC and 45 healthy controls were measured using enzyme-linked immunosorbent assay or Millipore cancer multiplex assay. The results demonstrated that circulating pGSN levels were significantly lower in patients with HNC than in healthy controls. Moreover, circulating pGSN outperformed other candidate biomarkers as an independent diagnostic biomarker of HNC in both sensitivity (82.7%) and specificity (95.6%). Receiver operating characteristic curves indicated that combined pGSN and sFasL levels further augmented this sensitivity (90.6%) for early disease detection. Moreover, higher pGSN levels predicted improved prognosis at both 5-year overall survival and progression-free survival. In conclusion, circulating pGSN could be an independent predictor of favorable clinical outcomes and a novel biomarker for the early HNC detection in combination with sFasL. View Full-Text
Keywords: plasma gelsolin; sFasL; circulating biomarker; head and neck cancer; diagnosis plasma gelsolin; sFasL; circulating biomarker; head and neck cancer; diagnosis
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MDPI and ACS Style

Chiu, C.-T.; Wang, P.-W.; Asare-Werehene, M.; Tsang, B.K.; Shieh, D.-B. Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand. Cancers 2020, 12, 1569. https://doi.org/10.3390/cancers12061569

AMA Style

Chiu C-T, Wang P-W, Asare-Werehene M, Tsang BK, Shieh D-B. Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand. Cancers. 2020; 12(6):1569. https://doi.org/10.3390/cancers12061569

Chicago/Turabian Style

Chiu, Chen-Tzu, Pei-Wen Wang, Meshach Asare-Werehene, Benjamin K. Tsang, and Dar-Bin Shieh. 2020. "Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand" Cancers 12, no. 6: 1569. https://doi.org/10.3390/cancers12061569

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