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Article

Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells

by
Chien-Hung Lin
1,2,3,4,
Hsin-Hui Wang
1,5,
Tsung-Hsien Chen
6,
Ming-Chang Chiang
3,
Peir-Haur Hung
6,7,*,† and
Yann-Jang Chen
1,2,8,†
1
Department of Pediatrics, Taipei Veterans General Hospital, Taipei 11217, Taiwan
2
Institute of Clinical Medicine, National Yang-Ming University, Taipei 11221, Taiwan
3
Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei 242304, Taiwan
4
Department of Pediatrics, Zhongxing Branch, Taipei City Hospital, Taipei 10341, Taiwan
5
Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei 11221, Taiwan
6
Department of Internal Medicine, Ditmanson Medical Foundation Chia-yi Christian Hospital, Chiayi 60002, Taiwan
7
Department of Applied Life Science and Health, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan
8
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 11221, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cancers 2020, 12(4), 973; https://doi.org/10.3390/cancers12040973
Submission received: 9 January 2020 / Revised: 31 March 2020 / Accepted: 2 April 2020 / Published: 15 April 2020
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Abstract

Short noncoding endogenous RNAs, including microRNAs (miRNAs), are associated with the development and metastasis of multiple cancers. Epigallocatechin gallate (EGCG), the most active and abundant polyphenol in green tea, plays a crucial role in the modulation of miRNA expression, which is related to changes in cancer progression. In the present study, we explore whether EGCG exerts its suppressive effects on nasopharyngeal carcinoma (NPC) cells through miRNA regulation. The anoikis-resistant sphere-forming NPC cells grown under anchorage-independent conditions exhibit enhanced migratory properties, which were inhibited by EGCG treatment. The miR-296 level was lower in the anoikis-resistant cells than in the monolayer parental cells; however, miR-296 was significantly upregulated after EGCG treatment. We demonstrate that miR-296 is involved in the inhibitory effects of EGCG on the anoikis-resistant NPC cells through the downregulation of signal transducer and activator of transcription 3 (STAT3) activation. Our study is the first to demonstrate that EGCG inhibited the migratory properties of anoikis-resistant cells by modulating the expression of miRNA in NPC cells. Our results indicate the novel effects of EGCG on miRNA regulation to inhibit an invasive phenotype of NPC as well as the regulatory role of miR-296.
Keywords: microRNA; epigallocatechin gallate (EGCG); nasopharyngeal carcinoma (NPC); cancer cell migration microRNA; epigallocatechin gallate (EGCG); nasopharyngeal carcinoma (NPC); cancer cell migration

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MDPI and ACS Style

Lin, C.-H.; Wang, H.-H.; Chen, T.-H.; Chiang, M.-C.; Hung, P.-H.; Chen, Y.-J. Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells. Cancers 2020, 12, 973. https://doi.org/10.3390/cancers12040973

AMA Style

Lin C-H, Wang H-H, Chen T-H, Chiang M-C, Hung P-H, Chen Y-J. Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells. Cancers. 2020; 12(4):973. https://doi.org/10.3390/cancers12040973

Chicago/Turabian Style

Lin, Chien-Hung, Hsin-Hui Wang, Tsung-Hsien Chen, Ming-Chang Chiang, Peir-Haur Hung, and Yann-Jang Chen. 2020. "Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells" Cancers 12, no. 4: 973. https://doi.org/10.3390/cancers12040973

APA Style

Lin, C.-H., Wang, H.-H., Chen, T.-H., Chiang, M.-C., Hung, P.-H., & Chen, Y.-J. (2020). Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells. Cancers, 12(4), 973. https://doi.org/10.3390/cancers12040973

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