A Novel Four-Gene Score to Predict Pathologically Complete (R0) Resection and Survival in Pancreatic Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. The Four-Gene Score Is Elevated in Pancreatic Cancer Tumors
2.2. The Four-Gene Score Correlates with Pathological Grade and MKI67 Expression, and Was Elevated in Metastatic Pancreatic Cancer
2.3. Tumors with High Four-Gene Score Have Enriched Expression of Cell Proiferation-Related and Pro-Cancerous Gene Sets
2.4. Pancreatic Cancer with High Four-Gene Sore Have Higher KRAS and CDKN2A Gene Alterations, and Enhanced Signaling of KRAS, p53, TGF-β, and E2F Target Pathways
2.5. Tumors with High Four-Gene Score Have High Levels of Interferon -Γ Response and Cytolytic Activity
2.6. The Four-Gene Score Level Associates with Drug Sensitivity to Sorafenib in Primary Pancreatic Cancer, and Paclitaxel and Doxorubicin in Metastatic Pancreatic Cancer
2.7. Pancreatic Cancer with a High Four-Gene Score Was Significantly Associated with Worse Survival and Pathologically Margin-Positive Resection
3. Discussion
4. Materials and Methods
4.1. Pancreatic Cancer Cohorts and Their Data
4.2. Gene Set Expression Analyses
4.3. Cell Composition Fraction Estimation
4.4. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Oshi, M.; Tokumaru, Y.; Patel, A.; Yan, L.; Matsuyama, R.; Endo, I.; Katz, M.H.G.; Takabe, K. A Novel Four-Gene Score to Predict Pathologically Complete (R0) Resection and Survival in Pancreatic Cancer. Cancers 2020, 12, 3635. https://doi.org/10.3390/cancers12123635
Oshi M, Tokumaru Y, Patel A, Yan L, Matsuyama R, Endo I, Katz MHG, Takabe K. A Novel Four-Gene Score to Predict Pathologically Complete (R0) Resection and Survival in Pancreatic Cancer. Cancers. 2020; 12(12):3635. https://doi.org/10.3390/cancers12123635
Chicago/Turabian StyleOshi, Masanori, Yoshihisa Tokumaru, Ankit Patel, Li Yan, Ryusei Matsuyama, Itaru Endo, Matthew H.G. Katz, and Kazuaki Takabe. 2020. "A Novel Four-Gene Score to Predict Pathologically Complete (R0) Resection and Survival in Pancreatic Cancer" Cancers 12, no. 12: 3635. https://doi.org/10.3390/cancers12123635