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Open AccessReview

MicroRNAs and Metastasis

by Carla Solé 1 and Charles H. Lawrie 1,2,3,*
1
Molecular Oncology Group, Biodonostia Research Institute, 20014 San Sebastián, Spain
2
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
3
Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(1), 96; https://doi.org/10.3390/cancers12010096
Received: 27 November 2019 / Revised: 20 December 2019 / Accepted: 27 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Role of miRNAs in Cancer—Analysis of Their Targetome)
Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis. The role of miRNAs in the metastatic process is beginning to be explored. However, much is still to be understood. In this review, we present the accumulating evidence for the importance of miRNAs in metastasis as key regulators of this hallmark of cancer. View Full-Text
Keywords: miRNA; metastasis; cancer; liquid biopsies miRNA; metastasis; cancer; liquid biopsies
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Solé, C.; Lawrie, C.H. MicroRNAs and Metastasis. Cancers 2020, 12, 96.

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