MicroRNAs and Metastasis
Abstract
:Graphical Abstract
1. Introduction
2. Metastasis—Promoting miRNAs
3. Metastasis—Suppressing miRNAs
4. Metastasis and Circulating miRNAs
5. The Metastatic Targetome
6. Concluding Remarks and Future Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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miRNA | Cancer | Express. | Sample | Target | Ref |
---|---|---|---|---|---|
Let-7 | Breast | Low | Cells & Tissue | RAS & HMGA2 | [14] |
miR-7 | Breast | Low | Cells & Tissue | FAK | [58] |
miR-10b | Breast | High | Cells & Tissue | HOXD10 | [13] |
miR-26a/b | HNSCC | Low | Cells & Tissue | LOXL2 | [45] |
miR-29 family | HNSCC | Low | Cells | LAMC2 & ITGA6 | [44] |
miR-29 family | HNSCC | Low | Cells & Tissue | LOXL2 | [45] |
miR-29 family | ccRCC | Low | Cells & Tissue | LOXL2 | [46] |
miR-29a | Breast | High | Cells & Tissue | SUV420H2 | [25] |
miR-29c | Lung | Low | Cells | Integrin β1 & MMP2 | [48] |
miR-31 | Breast | Low | Cells | Integrin α subunits | [60] |
miR-31 | Breast | Low | Cells & Tissue | WAVE3 | [59] |
miR-33b | Breast | Low | Cells & Tissue | HMGA2, SALL4 & Twist1 | [65] |
miR-34 | CRC | Low | Cells | ZEB1 & Slug | [68] |
miR-34a/b/c | CRC | Low | Cells | Snail | [170] |
miR-34a | Breast | Low | Cells & Tissue | CXCL10 | [171] |
miR-34c | Breast | Low | Cells & Tissue | GIT1 | [66] |
miR-93 | Endometrial | High | Cells & Tissue | FOXA1 | [29] |
miR-96 | Breast | High | Cells & Tissue | PTPN9 | [23] |
miR-96 | HCC | High | Cells & Tissue | ephrinA5 | [172] |
miR-101 | Ovarian | Low | Cells | ZEB1 & ZEB2 | [69] |
miR-101 | NSCLC | Low | Cells & Tissue | ZEB1 | [173] |
miR-105 | Breast | High | Cells, Tissue & Serum | ZO-1 | [17] |
miR-124 | Breast | Low | Cells & Tissue | ZEB2 | [174] |
miR-124 | Breast | Low | Cells & Tissue | IL-11 | [63] |
miR-124 | CRC | Low | Cells & Tissue | ROCK1 | [55] |
miR-128-3p | ESCC | Low | Cells & Tissue | ZEB1 | [175] |
miR-130a | Breast | Low | Cells | FOSL1 | [26] |
miR-132 | NSCLC | Low | Cells & Tissue | ZEB2 | [73] |
miR-132 | CRC | Low | Cells & Tissue | ZEB2 | [72] |
miR-135a | Breast | High | Cells & Tissue | HOXA10 | [20] |
miR-135a | HCC | High | Cells & Tissue | FOXO1 | [22] |
miR-135a | Gastric | Low | Cells & Tissue | ROCK1 | [56] |
miR-135b | Breast | High | Cells & Tissue | APC | [21] |
miR-138 | Breast | Low | Cells & Tissue | ROCK1 | [57] |
miR-139-5p | Glioblastoma | Low | Cells & Tissue | ZEB1 & ZEB2 | [70] |
miR-141 | Breast | Low | Cells & Tissue | HIPK1 | [176] |
miR-141 | Prostate | Low | Cells & Tissue | Rho GTases, CD44 & EZH2 | [43] |
miR-150 | Breast | Low | Cells & Tissue | HMGA2 | [62] |
miR-154 | Breast | Low | Cells & Tissue | E2F5 | [61] |
miR-181b | Breast | High | Cells & Tissue | YWHAG | [18] |
miR-182 | HCC | High | Cells & Tissue | ephrinA5 | [172] |
miR-186-5p | CRC | Low | Cells | ZEB1 | [177] |
miR-190 | Breast | Low | Cells | STC2 | [178] |
miR-190 | Breast | Low | Cells & Tissue | SMAD2 | [179] |
miR-194 | Ovarian | High | Cells & Tissue | PTPN12 | [37] |
miR-197 | HCC | High | Cells & Tissue | Axin-2, NKD1 & DKK2 | [30] |
miR-200 | Breast | Low | Cells & Tissue | ZEB1 & ZEB2 | [39] |
miR-200a/b | Breast | Low | Cells | ZEB1 & ZEB2 | [38] |
miR-200c | Breast | Low | Cells | CRKL | [180] |
miR-200c | Breast | Low | Cells | ZEB1 | [181] |
miR-200c | Breast | Low | Cells & Tissue | HIPK1 | [176] |
miR-203 | HNSCC | Low | Cells & Tissue | LASP1, SPARC & NUAK | [49] |
miR-203 | Breast | Low | Cells | Slug | [50] |
miR-203 | CRC | Low | Cells & Tissue | EIF5A2 | [54] |
miR-203 | Melanoma | Low | Cells & Tissue | Slug | [51] |
miR-203 | Ovarian | Low | Cells & Tissue | BIRC5 | [52] |
miR-203 | Gastric | Low | Cells & Tissue | Annexin A4 | [53] |
miR-205 | Breast | Low | Cells | ZEB1 | [182] |
miR-205 | Breast | Low | Cells & Tissue | ZEB1 & ZEB2 | [39] |
miR-210 | Breast | High | Cells & Tissue | E-Cadherin & Snail | [24] |
miR-215 | NSCLC | Low | Cells & Tissue | ZEB2 | [71] |
miR-218 | HNSCC | Low | Cells & Tissue | LOXL2 | [45] |
miR-374a | Breast | High | Cells & Tissue | WIF1, PTEN & WNT5A | [19] |
miR-409-3p | Osteosarcoma | Low | Cells & Tissue | ZEB1 | [183] |
miR-429 | Breast | Low | Cells | ZEB1 & ZEB2 | [38] |
miR-504 | NSCLC | Low | Cells & Tissue | LOXL2 | [47] |
miR-508-3p | Breast | Low | Cells & Tissue | ZEB1 | [184] |
miR-520c | Gastic | High | Cells & Tissue | IRF2 | [32] |
miR-574-5p | NSCLC | High | Cells, Tissue & Serum | PTPRU | [36] |
miR-577 | Gastric | High | Cells & Tissue | SDPR | [31] |
miR-641 | Cervical | Low | Cells & Tissue | ZEB1 | [185] |
miR-708-3p | Breast | Low | Cells & Tissue | ZEB1, CDH2 & Vimentin | [186] |
miR-1204 | Breast | High | Cells & Tissue | VDR | [28] |
miR-1269a | Colorectal | High | Cells & Tissue | Smad7 & HOXD10 | [33] |
miR-8084 | Breast | High | Cells, Tissue & Serum | ING2 | [27] |
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Solé, C.; Lawrie, C.H. MicroRNAs and Metastasis. Cancers 2020, 12, 96. https://doi.org/10.3390/cancers12010096
Solé C, Lawrie CH. MicroRNAs and Metastasis. Cancers. 2020; 12(1):96. https://doi.org/10.3390/cancers12010096
Chicago/Turabian StyleSolé, Carla, and Charles H. Lawrie. 2020. "MicroRNAs and Metastasis" Cancers 12, no. 1: 96. https://doi.org/10.3390/cancers12010096