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Human Tumor-Infiltrating Dendritic Cells: From In Situ Visualization to High-Dimensional Analyses
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Dendritic Cell-Based and Other Vaccination Strategies for Pediatric Cancer

1
Division of Hematology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
2
Center for Cell Therapy & Regenerative Medicine, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
3
Tumor Immunology Group, Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine & Health Sciences, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium
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Division of Pediatric Hemato-Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium
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Center for Oncological Research, Faculty of Medicine & Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(9), 1396; https://doi.org/10.3390/cancers11091396
Received: 29 July 2019 / Revised: 9 September 2019 / Accepted: 10 September 2019 / Published: 19 September 2019
(This article belongs to the Special Issue Tumour Associated Dendritic Cells)
Dendritic cell-based and other vaccination strategies that use the patient’s own immune system for the treatment of cancer are gaining momentum. Most studies of therapeutic cancer vaccination have been performed in adults. However, since cancer is one of the leading causes of death among children past infancy in the Western world, the hope is that this form of active specific immunotherapy can play an important role in the pediatric population as well. Since children have more vigorous and adaptable immune systems than adults, therapeutic cancer vaccines are expected to have a better chance of creating protective immunity and preventing cancer recurrence in pediatric patients. Moreover, in contrast to conventional cancer treatments such as chemotherapy, therapeutic cancer vaccines are designed to specifically target tumor cells and not healthy cells or tissues. This reduces the likelihood of side effects, which is an important asset in this vulnerable patient population. In this review, we present an overview of the different therapeutic cancer vaccines that have been studied in the pediatric population, with a main focus on dendritic cell-based strategies. In addition, new approaches that are currently being investigated in clinical trials are discussed to provide guidance for further improvement and optimization of pediatric cancer vaccines. View Full-Text
Keywords: dendritic cells; pediatric cancer; tumor vaccination; immunotherapy dendritic cells; pediatric cancer; tumor vaccination; immunotherapy
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MDPI and ACS Style

de Bruijn, S.; Anguille, S.; Verlooy, J.; Smits, E.L.; van Tendeloo, V.F.; de Laere, M.; Norga, K.; Berneman, Z.N.; Lion, E. Dendritic Cell-Based and Other Vaccination Strategies for Pediatric Cancer. Cancers 2019, 11, 1396. https://doi.org/10.3390/cancers11091396

AMA Style

de Bruijn S, Anguille S, Verlooy J, Smits EL, van Tendeloo VF, de Laere M, Norga K, Berneman ZN, Lion E. Dendritic Cell-Based and Other Vaccination Strategies for Pediatric Cancer. Cancers. 2019; 11(9):1396. https://doi.org/10.3390/cancers11091396

Chicago/Turabian Style

de Bruijn, Sévérine; Anguille, Sébastien; Verlooy, Joris; Smits, Evelien L.; van Tendeloo, Viggo F.; de Laere, Maxime; Norga, Koenraad; Berneman, Zwi N.; Lion, Eva. 2019. "Dendritic Cell-Based and Other Vaccination Strategies for Pediatric Cancer" Cancers 11, no. 9: 1396. https://doi.org/10.3390/cancers11091396

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