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Open AccessReview

STAT3, a Master Regulator of Anti-Tumor Immune Response

Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, INSERM LNC UMR1231, University of Bourgogne Franche-Comté, F-21000 Dijon, France
Authors to whom correspondence should be addressed.
Cancers 2019, 11(9), 1280;
Received: 18 July 2019 / Revised: 29 August 2019 / Accepted: 29 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Targeting STAT3 and STAT5 in Cancer)
Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer progression is dependent on the activation or repression of transcription programs involved in the proliferation/activation of lymphoid and myeloid cells. One of the main transcription factors involved in many of these pathways is the signal transducer and activator of transcription 3 (STAT3). In this review we will focus on the role of STAT3 and its regulation, e.g., by phosphorylation or acetylation in immune cells and how it might impact immune cell function and tumor progression. Moreover, we will review the ability of STAT3 to regulate checkpoint inhibitors. View Full-Text
Keywords: STAT3; cancer; CD4+ T cells; CD8+ T cells; myeloid cells; immune check point STAT3; cancer; CD4+ T cells; CD8+ T cells; myeloid cells; immune check point
MDPI and ACS Style

Rébé, C.; Ghiringhelli, F. STAT3, a Master Regulator of Anti-Tumor Immune Response. Cancers 2019, 11, 1280.

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