Next Article in Journal
Isoliquiritigenin Suppresses E2-Induced Uterine Leiomyoma Growth through the Modulation of Cell Death Program and the Repression of ECM Accumulation
Previous Article in Journal
High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells
Previous Article in Special Issue
Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview

MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

1
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan
2
Department of Gynecology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
3
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
4
Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
5
Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Sapporo 003-0804, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equaly.
Cancers 2019, 11(8), 1130; https://doi.org/10.3390/cancers11081130
Received: 8 July 2019 / Revised: 1 August 2019 / Accepted: 1 August 2019 / Published: 7 August 2019
(This article belongs to the Special Issue Role of miRNAs in Cancer—Analysis of Their Targetome)
  |  
PDF [1448 KB, uploaded 7 August 2019]
  |  

Abstract

MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development. View Full-Text
Keywords: microRNA-361; EMT; angiogenesis; tumor microenvironment; cancer diagnosis; cancer treatment microRNA-361; EMT; angiogenesis; tumor microenvironment; cancer diagnosis; cancer treatment
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Xu, D.; Dong, P.; Xiong, Y.; Yue, J.; Ihira, K.; Konno, Y.; Kobayashi, N.; Todo, Y.; Watari, H. MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation. Cancers 2019, 11, 1130.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top