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HOX Genes in High Grade Ovarian Cancer

1
Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YS, UK
2
Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1107; https://doi.org/10.3390/cancers11081107
Received: 3 July 2019 / Revised: 24 July 2019 / Accepted: 31 July 2019 / Published: 3 August 2019
(This article belongs to the Special Issue HOX Genes in Cancer)
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PDF [370 KB, uploaded 3 August 2019]
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Abstract

HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs. View Full-Text
Keywords: HOX; ovarian cancer HOX; ovarian cancer
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Idaikkadar, P.; Morgan, R.; Michael, A. HOX Genes in High Grade Ovarian Cancer. Cancers 2019, 11, 1107.

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