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Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer

by Konstantina Georgila 1,2,†, Dimitra Vyrla 1,2,† and Elias Drakos 2,*
1
Department of Biology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece
2
Department of Pathology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(8), 1097; https://doi.org/10.3390/cancers11081097
Received: 20 June 2019 / Revised: 25 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to better estimation of cancer risk, early cancer diagnosis, follow up, and prognosis stratification of cancer patients. In addition, recent in vitro and animal studies disclose a more direct, tumor suppressive role of ApoA-I in cancer pathogenesis, which involves anti-inflammatory and immune-modulatory mechanisms. Herein, we review recent epidemiologic, clinicopathologic, and mechanistic studies investigating the role of ApoA-I in cancer biology, which suggest that enhancing the tumor suppressive activity of ApoA-I may contribute to better cancer prevention and treatment. View Full-Text
Keywords: apolipoprotein A-I; HDL; cancer; immunity; inflammation; review apolipoprotein A-I; HDL; cancer; immunity; inflammation; review
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Georgila, K.; Vyrla, D.; Drakos, E. Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer. Cancers 2019, 11, 1097.

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