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Open AccessReview

Persistent Organic Pollutants and Breast Cancer: A Systematic Review and Critical Appraisal of the Literature

by Kaoutar Ennour-Idrissi 1,2,3,4, Pierre Ayotte 3,5,6 and Caroline Diorio 1,2,3,4,*
1
Axe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC G1E 6W2, Canada
2
Centre de Recherche sur le Cancer, Université Laval, Quebec City, QC G1R 3S3, Canada
3
Département de Médecine Sociale et Préventive, Faculté de Médecine, Université Laval, Quebec City, QC G1V 0A6, Canada
4
Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Quebec City, QC G1S 4L8, Canada
5
Axe santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Université Laval, Quebec City, QC G1E 6W2, Canada
6
Centre de Toxicologie du Québec (CTQ), INSPQ, Quebec City, QC G1V 5B3, Canada
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1063; https://doi.org/10.3390/cancers11081063
Received: 4 July 2019 / Revised: 23 July 2019 / Accepted: 24 July 2019 / Published: 27 July 2019
(This article belongs to the Special Issue Role of Natural Bioactive Compounds in the Rise and Fall of Cancers)
Persistent organic pollutants (POPs) bioaccumulate in the food chain and have been detected in human blood and adipose tissue. Experimental studies demonstrated that POPs can cause and promote growth of breast cancer. However, inconsistent results from epidemiological studies do not support a causal relationship between POPs and breast cancer in women. To identify individual POPs that are repeatedly found to be associated with both breast cancer incidence and progression, and to demystify the observed inconsistencies between epidemiological studies, we conducted a systematic review of 95 studies retrieved from three main electronic databases. While no clear pattern of associations between blood POPs and breast cancer incidence could be drawn, POPs measured in breast adipose tissue were more clearly associated with higher breast cancer incidence. POPs were more consistently associated with worse breast cancer prognosis whether measured in blood or breast adipose tissue. In contrast, POPs measured in adipose tissue other than breast were inversely associated with both breast cancer incidence and prognosis. Differences in biological tissues used for POPs measurement and methodological biases explain the discrepancies between studies results. Some individual compounds associated with both breast cancer incidence and progression, deserve further investigation. View Full-Text
Keywords: breast cancer; persistent organic pollutants; breast cancer risk; breast cancer prognostic; systematic review breast cancer; persistent organic pollutants; breast cancer risk; breast cancer prognostic; systematic review
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Ennour-Idrissi, K.; Ayotte, P.; Diorio, C. Persistent Organic Pollutants and Breast Cancer: A Systematic Review and Critical Appraisal of the Literature. Cancers 2019, 11, 1063.

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