Next Article in Journal
Dose-Dependent Sorafenib-Induced Immunosuppression Is Associated with Aberrant NFAT Activation and Expression of PD-1 in T Cells
Next Article in Special Issue
Exercise Intervention Improves Clinical Outcomes, but the “Time of Session” is Crucial for Better Quality of Life in Breast Cancer Survivors: A Systematic Review and Meta-Analysis
Previous Article in Journal
Clinical Diagnosis of Gastrointestinal Stromal Tumor (GIST): From the Molecular Genetic Point of View
Previous Article in Special Issue
Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle

Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study

Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 42601, Korea
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang 10408, Korea
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Korea
Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul 07804, Korea
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
Department of Radiation Oncology, Chonnam National University Medical School, Gwangju 61469, Korea
Department of Radiation Oncology, St. Vincent′s Hospital, The Catholic University of Korea College of Medicine, Seoul 06591, Korea
Department of Radiation Oncology, Ajou University School of Medicine, Suwon 16499, Korea
Department of Radiation Oncology, Dong-A University Hospital, Dong-A University School of Medicine, Busan 49201, Korea
Department of Radiation Oncology, Chonbuk National University Medical School, Jeonju 54907, Korea
Department of Radiation Oncology, Wonju Severance Christian Hospital, Wonju 26426, Korea
Author to whom correspondence should be addressed.
These two authors contributed equally to this work.
Cancers 2019, 11(5), 680;
Received: 21 April 2019 / Revised: 8 May 2019 / Accepted: 13 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Treatment Strategies and Survival Outcomes in Breast Cancer)
PDF [472 KB, uploaded 21 May 2019]
  |     |  


This study evaluated the clinical significance of the lymph-node ratio (LNR) and its usefulness as an indicator of supraclavicular lymph-node radiation therapy (SCNRT) in pN1 breast cancer patients with disease-free survival (DFS) outcomes. We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). We compared their DFS according to LNR, with a cut-off value of 0.10. The median follow-up period was 66 months (range, 3–112). Treatment failed in 73 patients (6.5%) and there was no significant difference in DFS between the SCNRT group and non-SCNRT group. High LNR (>0.10) showed significantly worse DFS in both univariate and multivariate analyses (0.010 and 0.033, respectively). In a subgroup analysis, the effect of SCNRT on DFS differed significantly among patients with LNR > 0.10 (p = 0.013). High LNR can be used as an independent prognostic factor for pN1 breast cancer patients treated with partial mastectomy and postoperative radiotherapy. It may also be useful in deciding whether to perform SCNRT to improve DFS. View Full-Text
Keywords: breast cancer; radiotherapy; lymph-node ratio; disease-free survival breast cancer; radiotherapy; lymph-node ratio; disease-free survival

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kim, J.; Park, W.; Kim, J.H.; Choi, D.H.; Kim, Y.-J.; Lee, E.S.; Shin, K.H.; Kim, J.H.; Kim, K.; Kim, Y.B.; Ahn, S.-J.; Lee, J.H.; Chun, M.; Lee, H.-S.; Kim, J.S.; Cha, J. Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study. Cancers 2019, 11, 680.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top