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Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

1
National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany
2
OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany
3
German Cancer Consortium (DKTK), Partner site Dresden, 01307 Dresden, Germany
4
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology—OncoRay, 01307 Dresden, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(5), 616; https://doi.org/10.3390/cancers11050616
Received: 31 March 2019 / Revised: 21 April 2019 / Accepted: 26 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Targeting Head and Neck Cancer)
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells. View Full-Text
Keywords: head and neck squamous cell carcinoma; HNSCC; cancer stem cells; therapy resistance; biomarkers head and neck squamous cell carcinoma; HNSCC; cancer stem cells; therapy resistance; biomarkers
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Peitzsch, C.; Nathansen, J.; Schniewind, S.I.; Schwarz, F.; Dubrovska, A. Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications. Cancers 2019, 11, 616.

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