Next Article in Journal
Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications
Next Article in Special Issue
Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities
Previous Article in Journal
Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
Previous Article in Special Issue
High Mannose Binding Lectin (PFL) from Pseudomonas fluorescens Down-Regulates Cancer-Associated Integrins and Immune Checkpoint Ligand B7-H4
Open AccessReview

Integrins: Moonlighting Proteins in Invadosome Formation

Biomarkers and Molecular Signaling Group, Neurodegenerative Diseases Area Center for Biomedical Research of La Rioja, CIBIR, c.p., 26006 Logroño, Spain
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(5), 615;
Received: 29 March 2019 / Revised: 26 April 2019 / Accepted: 28 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue The Role of Integrins in Cancer)
Invadopodia are actin-rich protrusions developed by transformed cells in 2D/3D environments that are implicated in extracellular matrix (ECM) remodeling and degradation. These structures have an undoubted association with cancer invasion and metastasis because invadopodium formation in vivo is a key step for intra/extravasation of tumor cells. Invadopodia are closely related to other actin-rich structures known as podosomes, which are typical structures of normal cells necessary for different physiological processes during development and organogenesis. Invadopodia and podosomes are included in the general term ‘invadosomes,’ as they both appear as actin puncta on plasma membranes next to extracellular matrix metalloproteinases, although organization, regulation, and function are slightly different. Integrins are transmembrane proteins implicated in cell–cell and cell–matrix interactions and other important processes such as molecular signaling, mechano-transduction, and cell functions, e.g., adhesion, migration, or invasion. It is noteworthy that integrin expression is altered in many tumors, and other pathologies such as cardiovascular or immune dysfunctions. Over the last few years, growing evidence has suggested a role of integrins in the formation of invadopodia. However, their implication in invadopodia formation and adhesion to the ECM is still not well known. This review focuses on the role of integrins in invadopodium formation and provides a general overview of the involvement of these proteins in the mechanisms of metastasis, taking into account classic research through to the latest and most advanced work in the field. View Full-Text
Keywords: integrins; invadopodia; podosome; cancer; signaling; microenvironment; stromal cells; matrix; forces integrins; invadopodia; podosome; cancer; signaling; microenvironment; stromal cells; matrix; forces
Show Figures

Figure 1

MDPI and ACS Style

Peláez, R.; Pariente, A.; Pérez-Sala, Á.; Larrayoz, I.M. Integrins: Moonlighting Proteins in Invadosome Formation. Cancers 2019, 11, 615.

AMA Style

Peláez R, Pariente A, Pérez-Sala Á, Larrayoz IM. Integrins: Moonlighting Proteins in Invadosome Formation. Cancers. 2019; 11(5):615.

Chicago/Turabian Style

Peláez, Rafael; Pariente, Ana; Pérez-Sala, Álvaro; Larrayoz, Ignacio M. 2019. "Integrins: Moonlighting Proteins in Invadosome Formation" Cancers 11, no. 5: 615.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop