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Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications
Open AccessArticle

Amplification of the EGFR and CCND1 Are Coordinated and Play Important Roles in the Progression of Oral Squamous Cell Carcinomas

1
Department of Public Health, Chang Gung University, Tao-Yuan 33302, Taiwan
2
Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Tao-Yuan 33302, Taiwan
3
Department of Anatomy, Chang Gung University, Tao-Yuan 33302, Taiwan
4
Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou branch, Tao-Yuan 33302, Taiwan
5
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou branch, Tao-Yuan 33302, Taiwan
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(6), 760; https://doi.org/10.3390/cancers11060760
Received: 6 May 2019 / Revised: 23 May 2019 / Accepted: 25 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Targeting Head and Neck Cancer)
Oral squamous cell carcinoma (OSCC) is a common cancer in Taiwan and worldwide. To provide some clues for clinical management of OSCC, 72 advanced-stage OSCCs were analyzed using two microarray platforms (26 cases with Affymetrix 500 K and 46 cases with Affymetrix SNP 6.0). Genomic identification of significant targets in cancer analyses were used to identify significant copy number alterations (CNAs) using a q-value cutoff of 0.25. Among the several significant regions, 12 CNAs were common between these two platforms. Two gain regions contained the well-known oncogenes EGFR (7p11.2) and CCND1 (11q13.3) and several known cancer suppressor genes, such as FHIT (3p14.2–p12.1), FAT1 (4q35.1), CDKN2A (9p21.3), and ATM (11q22.3–q24.3), reside within the 10 deletion regions. Copy number gains of EGFR and CCND1 were further confirmed by fluorescence in situ hybridization and TaqMan CN assay, respectively, in 257 OSCC cases. Our results indicate that EGFR and CCND1 CNAs are significantly associated with clinical stage, tumor differentiation, and lymph node metastasis. Furthermore, EGFR and CCND1 CNAs have an additive effect on OSCC tumor progression. Thus, current genome-wide CNA analysis provides clues for future characterization of important oncogenes and tumor suppressor genes associated with the behaviors of the disease. View Full-Text
Keywords: copy number analysis; amplification; EGFR; CCND1; oral squamous cell carcinoma copy number analysis; amplification; EGFR; CCND1; oral squamous cell carcinoma
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Chien, H.-T.; Cheng, S.-D.; Liao, C.-T.; Wang, H.-M.; Huang, S.-F. Amplification of the EGFR and CCND1 Are Coordinated and Play Important Roles in the Progression of Oral Squamous Cell Carcinomas. Cancers 2019, 11, 760.

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