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Cancers 2019, 11(4), 478; https://doi.org/10.3390/cancers11040478

Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy

1
Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 44000, Pakistan
2
Department of Chemistry, GCU, 54000 Lahore, Pakistan
3
Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad 44000, Pakistan
4
Department of Obstetrics and Gynecology, Yeditepe University Hospital, 34755 Istanbul, Turkey
5
Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Pontedera, 56025 Pisa, Italy
6
Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty 050004, Kazakhstan
7
Department of General Surgery, Kazakhstan Medical University KSPH, Almaty 050004, Kazakhstan
8
Department of Biomedical Science, Institute of Biomedicine and Molecular Immunology “A. Monroy”, National Research Council, 90146 Palermo, Italy
9
Department of Agrifood, National Research Council Italy Institute of Sciences of Food Productions (CNR-ISPA) Via Lecce-Monteroni km 7, 73100 Lecce, Italy
10
Food Science and Technology Program, Division of Science and Technology, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, China
*
Author to whom correspondence should be addressed.
Received: 7 March 2019 / Revised: 24 March 2019 / Accepted: 25 March 2019 / Published: 4 April 2019
(This article belongs to the Special Issue Role of Natural Bioactive Compounds in the Rise and Fall of Cancers)
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Abstract

There has been a renewed interest in the identification of natural products having premium pharmacological properties and minimum off-target effects. In accordance with this approach, natural product research has experienced an exponential growth in the past two decades and has yielded a stream of preclinical and clinical insights which have deeply improved our knowledge related to the multifaceted nature of cancer and strategies to therapeutically target deregulated signaling pathways in different cancers. In this review, we have set the spotlight on the scientifically proven ability of berberine to effectively target a myriad of deregulated pathways. View Full-Text
Keywords: berberine; signaling pathways; oncogenic cascades; TRAIL; microRNAs; cancer therapy berberine; signaling pathways; oncogenic cascades; TRAIL; microRNAs; cancer therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Farooqi, A.A.; Qureshi, M.Z.; Khalid, S.; Attar, R.; Martinelli, C.; Sabitaliyevich, U.Y.; Nurmurzayevich, S.B.; Taverna, S.; Poltronieri, P.; Xu, B. Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy. Cancers 2019, 11, 478.

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