Next Article in Journal
MicroRNAs and Long Non-Coding RNAs and Their Hormone-Like Activities in Cancer
Previous Article in Journal
Ion Channels: New Actors Playing in Chemotherapeutic Resistance
Previous Article in Special Issue
Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Cancers 2019, 11(3), 377;

MRI of Uveal Melanoma

Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Department of Ophthalmology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 8 February 2019 / Revised: 8 March 2019 / Accepted: 12 March 2019 / Published: 17 March 2019
(This article belongs to the Special Issue Uveal Melanoma)
Full-Text   |   PDF [5790 KB, uploaded 21 March 2019]   |  


Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM. Current clinical MRI protocols, however, are not optimized for UM and therefore lack the quality for accurate assessments. We therefore developed a dedicated protocol at a 3 Tesla MRI, using an eye coil, consisting of multi-slice 2D sequences, different isotropic sequences and diffusion and perfusion-weighted images. This protocol was prospectively evaluated in 9 uveal melanoma patients. The multi-slice 2D sequences had the highest in-plane resolution, being the most suited for lesion characterization and local extension evaluation. The isotropic 3D Turbo-Spin Echo (TSE) sequences were the most suitable for accurate geometric measurements of the tumor and are therefore important for therapy planning. Diffusion and perfusion-weighted images aid in differentiating benign from malignant lesions and provide quantitative measures on tumor hemodynamics and cellularity, which have been reported to be effective in predicting and assessing treatment outcome. Overall, this dedicated MRI protocol provides high-quality imaging of UM, which can be used to improve its diagnosis, treatment planning, and follow-up. View Full-Text
Keywords: uveal melanoma; MRI; diffusion-weighted imaging; perfusion-weighted imaging uveal melanoma; MRI; diffusion-weighted imaging; perfusion-weighted imaging

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ferreira, T.A.; Grech Fonk, L.; Jaarsma-Coes, M.G.; van Haren, G.G.R.; Marinkovic, M.; Beenakker, J.-W.M. MRI of Uveal Melanoma. Cancers 2019, 11, 377.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top