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Cancers 2019, 11(3), 377; https://doi.org/10.3390/cancers11030377

MRI of Uveal Melanoma

1
Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
2
Department of Ophthalmology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 8 February 2019 / Revised: 8 March 2019 / Accepted: 12 March 2019 / Published: 17 March 2019
(This article belongs to the Special Issue Uveal Melanoma)
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Abstract

Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM. Current clinical MRI protocols, however, are not optimized for UM and therefore lack the quality for accurate assessments. We therefore developed a dedicated protocol at a 3 Tesla MRI, using an eye coil, consisting of multi-slice 2D sequences, different isotropic sequences and diffusion and perfusion-weighted images. This protocol was prospectively evaluated in 9 uveal melanoma patients. The multi-slice 2D sequences had the highest in-plane resolution, being the most suited for lesion characterization and local extension evaluation. The isotropic 3D Turbo-Spin Echo (TSE) sequences were the most suitable for accurate geometric measurements of the tumor and are therefore important for therapy planning. Diffusion and perfusion-weighted images aid in differentiating benign from malignant lesions and provide quantitative measures on tumor hemodynamics and cellularity, which have been reported to be effective in predicting and assessing treatment outcome. Overall, this dedicated MRI protocol provides high-quality imaging of UM, which can be used to improve its diagnosis, treatment planning, and follow-up. View Full-Text
Keywords: uveal melanoma; MRI; diffusion-weighted imaging; perfusion-weighted imaging uveal melanoma; MRI; diffusion-weighted imaging; perfusion-weighted imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ferreira, T.A.; Grech Fonk, L.; Jaarsma-Coes, M.G.; van Haren, G.G.R.; Marinkovic, M.; Beenakker, J.-W.M. MRI of Uveal Melanoma. Cancers 2019, 11, 377.

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