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Cancers 2019, 11(3), 376; https://doi.org/10.3390/cancers11030376

Ion Channels: New Actors Playing in Chemotherapeutic Resistance

1
Laboratoire de Physiologie Cellulaire et Moléculaire (EA 4667), Université de Picardie Jules Verne, UFR des Sciences, 33 Rue St Leu, 80039 Amiens, France
2
Service de Gynécologie Obstétrique, CHU Amiens Picardie, 80000 Amiens, France
3
Laboratoire d’Anatomie et Cytologie Pathologiques, CHU Amiens Picardie, 80000 Amiens, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 1 February 2019 / Revised: 7 March 2019 / Accepted: 12 March 2019 / Published: 16 March 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
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Abstract

In the battle against cancer cells, therapeutic modalities are drastically limited by intrinsic or acquired drug resistance. Resistance to therapy is not only common, but expected: if systemic agents used for cancer treatment are usually active at the beginning of therapy (i.e., 90% of primary breast cancers and 50% of metastases), about 30% of patients with early-stage breast cancer will have recurrent disease. Altered expression of ion channels is now considered as one of the hallmarks of cancer, and several ion channels have been linked to cancer cell resistance. While ion channels have been associated with cell death, apoptosis and even chemoresistance since the late 80s, the molecular mechanisms linking ion channel expression and/or function with chemotherapy have mostly emerged in the last ten years. In this review, we will highlight the relationships between ion channels and resistance to chemotherapy, with a special emphasis on the underlying molecular mechanisms. View Full-Text
Keywords: ion channels; cancer; chemoresistance ion channels; cancer; chemoresistance
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Kischel, P.; Girault, A.; Rodat-Despoix, L.; Chamlali, M.; Radoslavova, S.; Abou Daya, H.; Lefebvre, T.; Foulon, A.; Rybarczyk, P.; Hague, F.; Dhennin-Duthille, I.; Gautier, M.; Ouadid-Ahidouch, H. Ion Channels: New Actors Playing in Chemotherapeutic Resistance. Cancers 2019, 11, 376.

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