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Cancers 2019, 11(3), 324; https://doi.org/10.3390/cancers11030324

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer

1
Department of Biology, University of Naples ‘Federico II’, 80126 Naples, Italy
2
Department of Molecular Medicine and Medical Biotechnologies, University of Naples, ‘Federico II’, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Received: 31 January 2019 / Revised: 25 February 2019 / Accepted: 4 March 2019 / Published: 7 March 2019
(This article belongs to the Collection Histone Modification in Cancer)
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Abstract

Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA. View Full-Text
Keywords: LSD1; epigenetics; histone demethylase; cancer; lncRNAs LSD1; epigenetics; histone demethylase; cancer; lncRNAs
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Majello, B.; Gorini, F.; Saccà, C.D.; Amente, S. Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer. Cancers 2019, 11, 324.

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