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Cancers 2019, 11(2), 207; https://doi.org/10.3390/cancers11020207

Hydroxyethyl Starch-Based Nanoparticles Featured with Redox-Sensitivity and Chemo-Photothermal Therapy for Synergized Tumor Eradication

National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Received: 8 January 2019 / Revised: 25 January 2019 / Accepted: 2 February 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Hyperthermia-based Anticancer Treatments)
PDF [1966 KB, uploaded 11 February 2019]   |  

Abstract

Chemo-photothermal combination therapy could achieve synergistically enhanced efficiency against tumors. Nanocarriers with good safety and high efficiency for chemo- photothermal therapy are pressingly needed. A new type of hydroxyethyl starch (HES) based on nanoparticles (NPs) loaded with doxorubicin (DOX) and indocyanine green (ICG) was, thus, developed in this study. DOX-loaded HES conjugates with redox-sensitivity (HES-SS-DOX) were first synthesized and they were then combined with ICG to self-assemble into [email protected] NPs with controlled compositions and sizes via collaborative interactions. The optimal [email protected] NPs had good physical and photothermal stability in aqueous media and showed high photothermal efficiency in vivo. They were able to fast release the loaded DOX in response to the redox stimulus and the applied laser irradiation. Based on the H22-tumor-bearing mouse model, these NPs were found to tendentiously accumulate inside tumors in comparison to other major organs. The [email protected] NPs together with dose-designated laser irradiation were able to fully eradicate tumors with only one injection and one single subsequent laser irradiation on the tumor site during a 14-day treatment period. In addition, they showed almost no impairment to the body. The presently developed [email protected] NPs have good in vivo safety and highly efficient anti-tumor capability. These NPs in conjugation with laser irradiation have promising potential for chemo-photothermal cancer therapy in the clinic.
Keywords: hydroxyethyl starch; nanoparticle; doxorubicin; indocyanine green; redox-sensitivity; cancer chemo-photothermal therapy hydroxyethyl starch; nanoparticle; doxorubicin; indocyanine green; redox-sensitivity; cancer chemo-photothermal therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yu, C.; Liu, C.; Wang, S.; Li, Z.; Hu, H.; Wan, Y.; Yang, X. Hydroxyethyl Starch-Based Nanoparticles Featured with Redox-Sensitivity and Chemo-Photothermal Therapy for Synergized Tumor Eradication. Cancers 2019, 11, 207.

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