Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Result Brush | Sample Size and Average Age (Years) | ||
---|---|---|---|
Male | Female | Total | |
Positive | 63 | 26 | 89 |
59.3 | 67.7 | 61.7 | |
Suspicious | 23 | 33 | 56 |
67.9 | 66.9 | 67.3 | |
Doubtful | 65 | 85 | 150 |
60.3 | 69.0 | 65.3 | |
Negative | 457 | 600 | 1057 |
58.5 | 62.4 | 60.7 | |
Total | 608 | 744 | 1352 |
59.1 | 63.5 | 61.6 |
Diagnosis | Frequency | |
---|---|---|
Absolute | Relative | |
SCC | 105 | 7.8% |
Lichen | 260 | 19.2% |
Lichen erosivus | 138 | 10.2% |
Leukoplakia | 297 | 22.0% |
Proliferative verrucous leukoplakia | 20 | 1.5% |
Erythroplakia | 29 | 2.1% |
Other Lesions | 503 | 37.2% |
Total | 1352 |
Location | Frequency All Lesions | Frequency SCC | ||
---|---|---|---|---|
Absolute | Relative | Absolute | Relative | |
Border of tongue | 303 | 22.4% | 34 | 32.4% |
Back of tongue | 26 | 1.9% | 0 | 0% |
Floor of the mouth | 79 | 5.8% | 16 | 15.2% |
Buccal mucosa | 384 | 28.4% | 8 | 7.6% |
Tonsil | 8 | 0.6% | 2 | 1.9% |
Lip/Labial mucosa | 37 | 2.7% | 4 | 3.8% |
Palate | 106 | 7.8% | 11 | 10.5% |
Alveolar ridge | 409 | 30.3% | 30 | 28.6% |
Total | 1352 | 105 |
Test | Accuracy | Confidence Interval (CI) | Lower Endpoint | Upper Endpoint |
---|---|---|---|---|
Sensitivity | 95.6% | 95% | 0.945 | 0.967 |
Specificity | 84.9% | 95% | 0.830 | 0.868 |
Positive predictive value | 36.6% | 95% | 0.340 | 0.392 |
Negative predictive value | 99.5% | 95% | 0.992 | 0.999 |
Brush Result | Cancer Diagnosis | ||
---|---|---|---|
Positive | Negative | Total | |
Positive | 77 | 12 | 89 |
Suspicious | 15 | 41 | 56 |
Doubtful | 16 | 134 | 150 |
Negative | 5 | 1052 | 1057 |
Total | 113 | 1239 | 1352 |
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Deuerling, L.; Gaida, K.; Neumann, H.; Remmerbach, T.W. Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma. Cancers 2019, 11, 1813. https://doi.org/10.3390/cancers11111813
Deuerling L, Gaida K, Neumann H, Remmerbach TW. Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma. Cancers. 2019; 11(11):1813. https://doi.org/10.3390/cancers11111813
Chicago/Turabian StyleDeuerling, Lena, Kristin Gaida, Heinrich Neumann, and Torsten W. Remmerbach. 2019. "Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma" Cancers 11, no. 11: 1813. https://doi.org/10.3390/cancers11111813