Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors
Abstract
:1. Introduction
2. Results
2.1. Synthesis and Characterization of 115, 200 and 420 nm PD NPs
2.2. Cytotoxicity Effect of PD NPs Depends on Their Size
2.3. PD NPs Cytotoxicity in Tumor Cells Could be Related to Their Iron Affinity
2.4. DOX-Adsorbed PD NPs (DOX@PD NPs) Presented a Notable Antiproliferation Activity
3. Discussion
4. Materials and Methods
4.1. Chemicals
4.2. Synthesis and Characterization of PD NPs of Different Sizes
4.3. Cell Culture
4.4. Size-Dependent Cytotoxicity Effect of PD NPs
4.5. PD Iron-Affinity could Explain the Cytotoxicity of PD NPs in Tumor Cells
4.6. DOX Adsorption onto PD NPs
4.7. Antiproliferative Activity of DOX@PD NPs
4.8. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Nieto, C.; Vega, M.A.; Enrique, J.; Marcelo, G.; Martín del Valle, E.M. Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors. Cancers 2019, 11, 1679. https://doi.org/10.3390/cancers11111679
Nieto C, Vega MA, Enrique J, Marcelo G, Martín del Valle EM. Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors. Cancers. 2019; 11(11):1679. https://doi.org/10.3390/cancers11111679
Chicago/Turabian StyleNieto, Celia, Milena A. Vega, Jesús Enrique, Gema Marcelo, and Eva M. Martín del Valle. 2019. "Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors" Cancers 11, no. 11: 1679. https://doi.org/10.3390/cancers11111679