The Role of Post-Neoadjuvant Chemotherapy Tumor Volume for Prognostication and Treatment Guidance in Loco-Regionally Advanced Nasopharyngeal Carcinoma
Abstract
:1. Introduction
2. Results
2.1. Patient Characteristics and Treatment Outcomes
2.2. Prognostic Value of GTVp and GTVnd on Survivals
2.3. Construction of TNV Risk Grouping Using Tumor Volume and T-, N-Category
2.4. Performance of TNV Risk Grouping against Eighth Edition TNM Classification and Tumor Volume
2.5. Association of Treatment and Survivals in LA-NPC Stratified by TNV Grouping
3. Discussion
4. Materials and Methods
4.1. Patient Selection
4.2. Pretreatment and Post Chemotherapy Evaluation
4.3. Tumor Volume Measurement
4.4. Radiotherapy and Chemotherapy
4.5. Follow-Up
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristic | Patients (n = 4109) |
---|---|
Age (years) | |
Median | 44 |
IQR | 37–52 |
Sex, n (%) | |
Male | 3071 (74.7) |
Female | 1038 (25.3) |
Family history | |
None | 3090 (75.2) |
Yes | 1019 (24.8) |
WHO histologic type, n (%) | |
I | 24 (0.6) |
II | 85 (2.1) |
III | 4000 (97.3) |
T category, n (%) | |
T1 | 215 (5.2) |
T2 | 313 (7.6) |
T3 | 2194 (53.4) |
T4 | 1387 (33.8) |
N category, n (%) | |
N0 | 273 (6.6) |
N1 | 1785 (43.4) |
N2 | 1239 (30.2) |
N3 | 812 (19.8) |
Stage, n (%) | |
III | 2091 (50.9) |
IV | 2018 (49.1) |
GTVp (cm3), n (%) | |
Median | 48.3 |
IQR | 28.4–77.5 |
GTVnd (cm3), n (%) | |
Median | 11.2 |
IQR | 4.8–22.1 |
Treatment, n (%) | |
NACT + CCRT | 3331 (81.1) |
NACT + IMRT | 778 (18.9) |
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Share and Cite
Chen, F.-P.; Wen, D.-W.; Li, F.; Lin, L.; Kou, J.; Zheng, W.-H.; Li, L.; Zhou, G.-Q.; Sun, Y. The Role of Post-Neoadjuvant Chemotherapy Tumor Volume for Prognostication and Treatment Guidance in Loco-Regionally Advanced Nasopharyngeal Carcinoma. Cancers 2019, 11, 1632. https://doi.org/10.3390/cancers11111632
Chen F-P, Wen D-W, Li F, Lin L, Kou J, Zheng W-H, Li L, Zhou G-Q, Sun Y. The Role of Post-Neoadjuvant Chemotherapy Tumor Volume for Prognostication and Treatment Guidance in Loco-Regionally Advanced Nasopharyngeal Carcinoma. Cancers. 2019; 11(11):1632. https://doi.org/10.3390/cancers11111632
Chicago/Turabian StyleChen, Fo-Ping, Dan-Wan Wen, Feng Li, Li Lin, Jia Kou, Wei-Hong Zheng, Li Li, Guan-Qun Zhou, and Ying Sun. 2019. "The Role of Post-Neoadjuvant Chemotherapy Tumor Volume for Prognostication and Treatment Guidance in Loco-Regionally Advanced Nasopharyngeal Carcinoma" Cancers 11, no. 11: 1632. https://doi.org/10.3390/cancers11111632