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Destined to Die: Apoptosis and Pediatric Cancers
Review

Understanding and Targeting Apoptotic Pathways in Ovarian Cancer

1
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
2
Obstetrics and Gynecology, Harvard Medical School, Boston, MA 02115, USA
3
Gynecology and Oncology Division, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(11), 1631; https://doi.org/10.3390/cancers11111631
Received: 16 September 2019 / Revised: 17 October 2019 / Accepted: 18 October 2019 / Published: 24 October 2019
(This article belongs to the Special Issue Apoptosis in Cancer)
Ovarian cancer cells evade the immune system as well as chemotherapeutic and/or biologic treatments through inherent or acquired mechanisms of survival and drug resistance. Depending on the cell type and the stimuli, this threshold can range from external forces such as blunt trauma to programmed processes such as apoptosis, autophagy, or necroptosis. This review focuses on apoptosis, which is one form of programmed cell death. It highlights the multiple signaling pathways that promote or inhibit apoptosis and reviews current clinical therapies that target apoptotic pathways in ovarian cancer. View Full-Text
Keywords: apoptosis; ovarian cancer; chemoresistance; glycosylation; miRNA; clinical trials apoptosis; ovarian cancer; chemoresistance; glycosylation; miRNA; clinical trials
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MDPI and ACS Style

Al-Alem, L.F.; Baker, A.T.; Pandya, U.M.; Eisenhauer, E.L.; Rueda, B.R. Understanding and Targeting Apoptotic Pathways in Ovarian Cancer. Cancers 2019, 11, 1631. https://doi.org/10.3390/cancers11111631

AMA Style

Al-Alem LF, Baker AT, Pandya UM, Eisenhauer EL, Rueda BR. Understanding and Targeting Apoptotic Pathways in Ovarian Cancer. Cancers. 2019; 11(11):1631. https://doi.org/10.3390/cancers11111631

Chicago/Turabian Style

Al-Alem, Linah F.; Baker, Andrew T.; Pandya, Unnati M.; Eisenhauer, Eric L.; Rueda, Bo R. 2019. "Understanding and Targeting Apoptotic Pathways in Ovarian Cancer" Cancers 11, no. 11: 1631. https://doi.org/10.3390/cancers11111631

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