RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy
Abstract
:1. Introduction
2. DNA Damage Signaling Pathways
3. Homologous Recombination and DNA Repair
4. RAD52 Functions and Its Implications in Carcinogenesis
4.1. RAD52 Proprieties and Functions
4.2. RAD52 Expression and Regulation
4.3. RAD52 in Carcinogenesis
5. RAD52 as a Molecular Target for Cancer Therapy
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristic Type | Description |
---|---|
Name | Radiation sensitive 52 |
Symbol | RAD52 |
Molecular weight | 46169 Da |
Size | 418 amino acids |
Structure | Heptameric rings. Two domains (NTD and CTD) |
Map locus | Chromosome 12p12.2-13 |
Coding protein | DNA repair protein RAD52 homolog |
Function | DBSs repair by promoting the annealing of complementary single-stranded DNA and by RAD51 recombinase stimulation |
Primary localization | Nucleus |
Protein interactions | ABL1, RPA2, RAD51 |
Described polymorphisms | rs1060499, rs11571493, rs11571496, rs11571497, rs139916251 |
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Nogueira, A.; Fernandes, M.; Catarino, R.; Medeiros, R. RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy. Cancers 2019, 11, 1622. https://doi.org/10.3390/cancers11111622
Nogueira A, Fernandes M, Catarino R, Medeiros R. RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy. Cancers. 2019; 11(11):1622. https://doi.org/10.3390/cancers11111622
Chicago/Turabian StyleNogueira, Augusto, Mara Fernandes, Raquel Catarino, and Rui Medeiros. 2019. "RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy" Cancers 11, no. 11: 1622. https://doi.org/10.3390/cancers11111622