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Open AccessArticle

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

1
Department of Pediatric Oncology, Santobono-Pausilipon Hospital, 80123 Naples, Italy
2
Department of Translational Medical Science Pediatric Section, University of Naples Federico II, 80131 Naples, Italy
3
Pathology Unit, Santobono-Pausilipon Hospital, 80123 Naples, Italy
4
National Research Council (CNR), Institute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), 80145 Naples, Italy
5
CEINGE Biotecnologie avanzate, 80145 Naples, Italy
6
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1537; https://doi.org/10.3390/cancers11101537
Received: 6 September 2019 / Revised: 4 October 2019 / Accepted: 8 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Pediatric Brain Tumor)
Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical and histopathological factors, is particularly challenging because of their high molecular heterogeneity. Thus, tumors with identical histotypes could result in variable biological behaviors and prognoses. The PATZ1 gene has been recently shown to be expressed in adult gliomas, including glioblastomas, where it correlates with the proneural subtype and with a better prognosis. Here, we analyzed the expression of PATZ1 in pediatric gliomas, first at mRNA level in a public database, and then at protein level, by immunohistochemistry, in a cohort of 52 glial brain tumors from young patients aged from 6 months to 16 years. As for adult tumors, we show that PATZ1 is enriched in glial tumors compared to the normal brain, where it correlates positively and negatively with a proneural and mesenchymal signature, respectively. Moreover, we show that PATZ1 is expressed at variable levels in our cohort of tumors. Higher expression was detected in high-grade than low-grade gliomas, suggesting a correlation with the malignancy. Among high-grade gliomas, higher levels of PATZ1 have consistently been found to correlate with worse event-free survival. Therefore, our study may imply new diagnostic opportunities for pediatric gliomas. View Full-Text
Keywords: pediatric brain tumors; glioma; PATZ1; prognosis pediatric brain tumors; glioma; PATZ1; prognosis
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MDPI and ACS Style

Passariello, A.; Errico, M.E.; Donofrio, V.; Maestrini, M.; Zerbato, A.; Cerchia, L.; Capasso, M.; Capasso, M.; Fedele, M. PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas. Cancers 2019, 11, 1537.

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