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Review

Purine-Metabolising Enzymes and Apoptosis in Cancer

1
Dipartimento di Biologia, Unità di Biochimica, Via S. Zeno 51, 56127 Pisa, Italy
2
Dipartimento di Biologia, Unità di Fisiologia Generale, Via S. Zeno 31, 56127 Pisa, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to the work.
Cancers 2019, 11(9), 1354; https://doi.org/10.3390/cancers11091354
Received: 24 July 2019 / Revised: 3 September 2019 / Accepted: 7 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue Apoptosis in Cancer)
The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are regulated to meet the demand of nucleic acid precursors during proliferation. Among them, the salvage pathway enzymes seem to play the key role in replenishing the purine pool in dividing and tumour cells that require a greater amount of nucleotides. An imbalance in the purine pools is fundamental not only for preventing cell proliferation, but also, in many cases, to promote apoptosis. It is known that tumour cells harbour several mutations that might lead to defective apoptosis-inducing pathways, and this is probably at the basis of the initial expansion of the population of neoplastic cells. Therefore, knowledge of the molecular mechanisms that lead to apoptosis of tumoural cells is key to predicting the possible success of a drug treatment and planning more effective and focused therapies. In this review, we describe how the modulation of enzymes involved in purine metabolism in tumour cells may affect the apoptotic programme. The enzymes discussed are: ectosolic and cytosolic 5′-nucleotidases, purine nucleoside phosphorylase, adenosine deaminase, hypoxanthine-guanine phosphoribosyltransferase, and inosine-5′-monophosphate dehydrogenase, as well as recently described enzymes particularly expressed in tumour cells, such as deoxynucleoside triphosphate triphosphohydrolase and 7,8-dihydro-8-oxoguanine triphosphatase. View Full-Text
Keywords: purine salvage; apoptosis; CD73; cN-II; ADA; PNP; HPRT; IMPDH; SAMHD1; MTH1 purine salvage; apoptosis; CD73; cN-II; ADA; PNP; HPRT; IMPDH; SAMHD1; MTH1
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MDPI and ACS Style

Camici, M.; Garcia-Gil, M.; Pesi, R.; Allegrini, S.; Tozzi, M.G. Purine-Metabolising Enzymes and Apoptosis in Cancer. Cancers 2019, 11, 1354. https://doi.org/10.3390/cancers11091354

AMA Style

Camici M, Garcia-Gil M, Pesi R, Allegrini S, Tozzi MG. Purine-Metabolising Enzymes and Apoptosis in Cancer. Cancers. 2019; 11(9):1354. https://doi.org/10.3390/cancers11091354

Chicago/Turabian Style

Camici, Marcella, Mercedes Garcia-Gil, Rossana Pesi, Simone Allegrini, and Maria Grazia Tozzi. 2019. "Purine-Metabolising Enzymes and Apoptosis in Cancer" Cancers 11, no. 9: 1354. https://doi.org/10.3390/cancers11091354

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