Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis
Abstract
:1. Introduction
2. Multiple Smad Phospho-Isoforms Signaling Exist
3. PSmad3C Displays Cytostatic Activity
4. PSmad3L (Ser-213) Enhances Mitogenic Pathways
5. PSmad2L/C and pSmad3L/C Promote Pro-Tumorigenic/Fibrogenic Pathways
6. A Shift of Hepatocytic Phospho-Smad Signaling from the Tumor-Suppressive pSmad3C Pathway to Carcinogenic pSmad3L and Fibrogenic pSmad2L/C Pathways Observed during Hepatic Fibrocarcinogenesis
7. Effective Antiviral Treatment Can Reverse Phospho-Smad Signaling in Early Stages of Chronic Liver Disease
8. Implications for HCC Prevention and Therapy
9. EMT in Liver Fibrosis and HCC Progression
10. Conclusions
Conflicts of Interest
References
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Yoshida, K.; Matsuzaki, K.; Murata, M.; Yamaguchi, T.; Suwa, K.; Okazaki, K. Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis. Cancers 2018, 10, 183. https://doi.org/10.3390/cancers10060183
Yoshida K, Matsuzaki K, Murata M, Yamaguchi T, Suwa K, Okazaki K. Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis. Cancers. 2018; 10(6):183. https://doi.org/10.3390/cancers10060183
Chicago/Turabian StyleYoshida, Katsunori, Koichi Matsuzaki, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, and Kazuichi Okazaki. 2018. "Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis" Cancers 10, no. 6: 183. https://doi.org/10.3390/cancers10060183