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Cancers 2018, 10(2), 33; https://doi.org/10.3390/cancers10020033

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer

1,2,3,†
,
1,2,3,†
,
1,2,3
,
1,2,3
and
1,2,3,*
1
Department of Biochemistry, Cancer Stem Cell and Tumor Microenvironment Group, Universidad Autónoma de Madrid (UAM), Madrid 28029, Spain
2
Department of Cancer Biology, Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM, Madrid 28029, Spain
3
Chronic Diseases and Cancer Area—Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 15 January 2018 / Accepted: 23 January 2018 / Published: 26 January 2018
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
Full-Text   |   PDF [5196 KB, uploaded 29 January 2018]   |  

Abstract

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent chemoresistant nature and metastatic capacity of this tumor. The latter is believed to be mainly due to the existence of a subpopulation of highly plastic “stem”-like cells within the tumor, known as cancer stem cells (CSCs), which have been shown to have unique metabolic, autophagic, invasive, and chemoresistance properties that allow them to continuously self-renew and escape chemo-therapeutic elimination. As such, current treatments for the majority of PDAC patients are not effective and do not significantly impact overall patient survival (<7 months) as they do not affect the pancreatic CSC (PaCSC) population. In this context, it is important to highlight the need to better understand the characteristics of the PaCSC population in order to develop new therapies to target these cells. In this review, we will provide the latest updates and knowledge on the inherent characteristics of PaCSCs, particularly their unique biological properties including chemoresistance, epithelial to mesenchymal transition, plasticity, metabolism and autophagy. View Full-Text
Keywords: pancreatic cancer; cancer stem cells; plasticity; EMT; chemoresistance; autophagy; metastasis; hybrid cancer cell; metabolism pancreatic cancer; cancer stem cells; plasticity; EMT; chemoresistance; autophagy; metastasis; hybrid cancer cell; metabolism
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Valle, S.; Martin-Hijano, L.; Alcalá, S.; Alonso-Nocelo, M.; Sainz Jr., B. The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer. Cancers 2018, 10, 33.

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