Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset

Chen, Jen-Shi; Hung, Chia-Yen; Chang, Hung; Liu, Chien-Ting; Chen, Yen-Yang; Lu, Chang-Hsien; Chang, Pei-Hung; Hung, Yu-Shin; Chou, Wen-Chi

doi:10.3390/cancers10120501

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Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset

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Departments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, Taiwan

Division of Hematology-Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan

Department of Hematology-Oncology, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung 833, Taiwan

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Departments of Hematology-Oncology, Chang Gung Memorial Hospital at Chiayi, Chiayi 612, Taiwan

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Department of Hematology-Oncology, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan

Author to whom correspondence should be addressed.

Cancers 2018, 10(12), 501; https://doi.org/10.3390/cancers10120501

Received: 30 October 2018 / Revised: 30 November 2018 / Accepted: 9 December 2018 / Published: 10 December 2018

(This article belongs to the Special Issue Advances in Pancreatic Cancer Research)

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Abstract

Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. Methods: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed. The clinical characteristics of all patients were analyzed to identify independent predictors of VTE and their effects on survival outcome. Results: During the median follow-up period of 7.7 months (range, 0.6–55.6), VTE occurred in 67 (8.0%) of the 838 patients. Leukocyte count > 11,000/μL and presence of liver metastases were the independent predictors of VTE. Patients with VTE did not show significantly poorer survival outcomes than those without VTE. However, early-onset VTE that occurred within 1.5 months after chemotherapy initiation was an independent negative prognosticator for overall survival. Conclusion: VTE incidence was found to be lower in Asian patients with pancreatic cancer than in their Western counterparts. Early-onset VTE, but not late-onset VTE, is a negative prognosticator for survival outcomes. View Full-Text

Keywords: pancreatic cancer; venous thromboembolism; incidence; predictor; outcome

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MDPI and ACS Style

Chen, J.-S.; Hung, C.-Y.; Chang, H.; Liu, C.-T.; Chen, Y.-Y.; Lu, C.-H.; Chang, P.-H.; Hung, Y.-S.; Chou, W.-C. Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset. Cancers 2018, 10, 501. https://doi.org/10.3390/cancers10120501

AMA Style

Chen J-S, Hung C-Y, Chang H, Liu C-T, Chen Y-Y, Lu C-H, Chang P-H, Hung Y-S, Chou W-C. Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset. Cancers. 2018; 10(12):501. https://doi.org/10.3390/cancers10120501

Chicago/Turabian Style

Chen, Jen-Shi, Chia-Yen Hung, Hung Chang, Chien-Ting Liu, Yen-Yang Chen, Chang-Hsien Lu, Pei-Hung Chang, Yu-Shin Hung, and Wen-Chi Chou. 2018. "Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset" Cancers 10, no. 12: 501. https://doi.org/10.3390/cancers10120501

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Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset

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