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Cancers 2018, 10(10), 366;

Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA
The University of Kansas Cancer Center, Kansas City, KS 66160, USA
Author to whom correspondence should be addressed.
Received: 22 August 2018 / Revised: 22 September 2018 / Accepted: 23 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
PDF [1055 KB, uploaded 29 September 2018]


Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer. View Full-Text
Keywords: ovarian cancer; tumor-associated macrophages; peritoneal metastasis; tumor microenvironment ovarian cancer; tumor-associated macrophages; peritoneal metastasis; tumor microenvironment

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gupta, V.; Yull, F.; Khabele, D. Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy. Cancers 2018, 10, 366.

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