Next Article in Journal
The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential
Next Article in Special Issue
Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
Previous Article in Journal
Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women
Previous Article in Special Issue
Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer
Open AccessReview

Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

1
Department of Pharmaceutical Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
2
Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
3
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
4
Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Cancers 2018, 10(10), 358; https://doi.org/10.3390/cancers10100358
Received: 1 September 2018 / Revised: 25 September 2018 / Accepted: 25 September 2018 / Published: 27 September 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
The tumor microenvironment for epithelial ovarian cancer is complex and rich in bioactive molecules that modulate cell-cell interactions and stimulate numerous signal transduction cascades. These signals ultimately modulate all aspects of tumor behavior including progression, metastasis and therapeutic response. Many of the signaling pathways converge on the small GTPase Ras-related C3 botulinum toxin substrate (Rac)1. In addition to regulating actin cytoskeleton remodeling necessary for tumor cell adhesion, migration and invasion, Rac1 through its downstream effectors, regulates cancer cell survival, tumor angiogenesis, phenotypic plasticity, quiescence, and resistance to therapeutics. In this review we discuss evidence for Rac1 activation within the ovarian tumor microenvironment, mechanisms of Rac1 dysregulation as they apply to ovarian cancer, and the potential benefits of targeting aberrant Rac1 activity in this disease. The potential for Rac1 contribution to extraperitoneal dissemination of ovarian cancer is addressed. View Full-Text
Keywords: Rho-GTPase; Rac1; guanine nucleotide exchange factors (GEFs); GTPase activating proteins (GAPs); oncogene; oncoprotein; ovarian cancer; tumor microenvironment; bone niche; therapeutic targeting Rho-GTPase; Rac1; guanine nucleotide exchange factors (GEFs); GTPase activating proteins (GAPs); oncogene; oncoprotein; ovarian cancer; tumor microenvironment; bone niche; therapeutic targeting
Show Figures

Figure 1

MDPI and ACS Style

Hudson, L.G.; Gillette, J.M.; Kang, H.; Rivera, M.R.; Wandinger-Ness, A. Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. Cancers 2018, 10, 358. https://doi.org/10.3390/cancers10100358

AMA Style

Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A. Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. Cancers. 2018; 10(10):358. https://doi.org/10.3390/cancers10100358

Chicago/Turabian Style

Hudson, Laurie G.; Gillette, Jennifer M.; Kang, Huining; Rivera, Melanie R.; Wandinger-Ness, Angela. 2018. "Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase" Cancers 10, no. 10: 358. https://doi.org/10.3390/cancers10100358

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop