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Cancers 2018, 10(11), 406; https://doi.org/10.3390/cancers10110406

Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression

1
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47401, USA
2
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
3
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 12 September 2018 / Revised: 19 October 2018 / Accepted: 24 October 2018 / Published: 29 October 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
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Abstract

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not improved significantly over the last several decades. In order to improve therapeutic approaches and patient outcomes, there is a critical need for focused research towards better understanding of the disease. Recent findings have revealed that the tumor microenvironment plays an essential role in promoting cancer progression and metastasis. The tumor microenvironment consists of cancer cells and several different types of normal cells recruited and reprogrammed by the cancer cells to produce factors beneficial to tumor growth and spread. These normal cells present within the tumor, along with the various extracellular matrix proteins and secreted factors, constitute the tumor stroma and can compose 10–60% of the tumor volume. Cancer associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, and play a critical role in promoting many aspects of tumor function. This review will describe the various hypotheses about the origin of CAFs, their major functions in the tumor microenvironment in ovarian cancer, and will discuss the potential of targeting CAFs as a possible therapeutic approach. View Full-Text
Keywords: ovarian cancer; tumor microenvironment; cancer associated fibroblasts; fibroblast; cross-talk; invasion; angiogenesis; ECM; chemoresistance; therapy ovarian cancer; tumor microenvironment; cancer associated fibroblasts; fibroblast; cross-talk; invasion; angiogenesis; ECM; chemoresistance; therapy
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Dasari, S.; Fang, Y.; Mitra, A.K. Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression. Cancers 2018, 10, 406.

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