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Micromachines 2018, 9(8), 397; https://doi.org/10.3390/mi9080397

The Use of Microfluidic Technology for Cancer Applications and Liquid Biopsy

1
The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia
2
The School of Biomedical Engineering, Faculty of Engineering and Internet Technology, University of Technology Sydney, Ultimo, NSW 2007, Australia
3
Institute of Molecular Medicine, Sechenov First Moscow State University, Moscow 119991, Russia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 June 2018 / Revised: 3 August 2018 / Accepted: 7 August 2018 / Published: 10 August 2018
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Abstract

There is growing awareness for the need of early diagnostic tools to aid in point-of-care testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor and often presents with challenges and associated risks. Therefore, alternative sources of tumor biomarkers is needed. Liquid biopsy has gained attention due to its non-invasive sampling of tumor tissue and ability to serially assess disease via a simple blood draw over the course of treatment. Among the leading technologies developing liquid biopsy solutions, microfluidics has recently come to the fore. Microfluidic platforms offer cellular separation and analysis platforms that allow for high throughout, high sensitivity and specificity, low sample volumes and reagent costs and precise liquid controlling capabilities. These characteristics make microfluidic technology a promising tool in separating and analyzing circulating tumor biomarkers for diagnosis, prognosis and monitoring. In this review, the characteristics of three kinds of circulating tumor markers will be described in the context of cancer, circulating tumor cells (CTCs), exosomes, and circulating tumor DNA (ctDNA). The review will focus on how the introduction of microfluidic technologies has improved the separation and analysis of these circulating tumor markers. View Full-Text
Keywords: microfluidic; lab on a chip; circulating biomarkers; separation; cancer; liquid biopsy microfluidic; lab on a chip; circulating biomarkers; separation; cancer; liquid biopsy
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Kulasinghe, A.; Wu, H.; Punyadeera, C.; Warkiani, M.E. The Use of Microfluidic Technology for Cancer Applications and Liquid Biopsy. Micromachines 2018, 9, 397.

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