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Micromachines 2018, 9(12), 634;

Toward Exosome-Based Neuronal Diagnostic Devices

Department of Electrical Engineering, Kwangwoon University, 447-1 Wolgye, Nowon, Seoul 01897, Korea
Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul 02447, Korea
School of Biomedical Engineering, Korea University, Seoul 02841, Korea
Authors to whom correspondence should be addressed.
These authors have equally contributed to this work.
Received: 27 September 2018 / Revised: 16 November 2018 / Accepted: 22 November 2018 / Published: 29 November 2018
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Targeting exosome for liquid biopsy has gained significant attention for its diagnostic and therapeutic potential. For detecting neuronal disease diagnosis such as Alzheimer’s disease (AD), the main technique for identifying AD still relies on positron-emission tomography (PET) imaging to detect the presence of amyloid-β (Aβ). While the detection of Aβ in cerebrospinal fluid has also been suggested as a marker for AD, the lack of quantitative measurements has compromised existing assays. In cerebrospinal fluid, in addition to Aβ, T-Tau, and P-Tau, alpha-synuclein has been considered a biomarker of neurodegeneration. This review suggests that and explains how the exosome can be used as a neuronal diagnostic component. To this end, we summarize current progress in exosome preparation/isolation and quantification techniques and comment on the outlooks for neuronal exosome-based diagnostic techniques. View Full-Text
Keywords: Alzheimer’s disease; diagnostics; exosome; Parkinson’s disease Alzheimer’s disease; diagnostics; exosome; Parkinson’s disease

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Yoo, Y.K.; Lee, J.; Kim, H.; Hwang, K.S.; Yoon, D.S.; Lee, J.H. Toward Exosome-Based Neuronal Diagnostic Devices. Micromachines 2018, 9, 634.

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