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Micromachines 2018, 9(4), 163;

Light Manipulation in Inhomogeneous Liquid Flow and Its Application in Biochemical Sensing

School of Physics and Technology, Wuhan University, Wuhan 430070, China
Author to whom correspondence should be addressed.
Received: 29 January 2018 / Revised: 23 March 2018 / Accepted: 26 March 2018 / Published: 2 April 2018
(This article belongs to the Special Issue Advances in Optofluidics)
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Light manipulation has always been the fundamental subject in the field of optics since centuries ago. Traditional optical devices are usually designed using glasses and other materials, such as semiconductors and metals. Optofluidics is the combination of microfluidics and optics, which brings a host of new advantages to conventional solid systems. The capabilities of light manipulation and biochemical sensing are inherent alongside the emergence of optofluidics. This new research area promotes advancements in optics, biology, and chemistry. The development of fast, accurate, low-cost, and small-sized biochemical micro-sensors is an urgent demand for real-time monitoring. However, the fluid flow in the on-chip sensor is usually non-uniformed, which is a new and emerging challenge for the accuracy of optical detection. It is significant to reveal the principle of light propagation in an inhomogeneous liquid flow and the interaction between biochemical samples and light in flowing liquids. In this review, we summarize the current state of optofluidic lab-on-a-chip techniques from the perspective of light modulation by the unique dynamic properties of fluid in heterogeneous media, such as diffusion, heat transfer, and centrifugation etc. Furthermore, this review introduces several novel photonic phenomena in an inhomogeneous liquid flow and demonstrates their application in biochemical sensing. View Full-Text
Keywords: optofluidics; inhomogeneous medium; light manipulation; biochemical sensing optofluidics; inhomogeneous medium; light manipulation; biochemical sensing

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Zuo, Y.; Zhu, X.; Shi, Y.; Liang, L.; Yang, Y. Light Manipulation in Inhomogeneous Liquid Flow and Its Application in Biochemical Sensing. Micromachines 2018, 9, 163.

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