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Passive Mixing inside Microdroplets

Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China
Author to whom correspondence should be addressed.
Micromachines 2018, 9(4), 160;
Received: 31 January 2018 / Revised: 22 March 2018 / Accepted: 23 March 2018 / Published: 1 April 2018
(This article belongs to the Special Issue Advances in Optofluidics)
PDF [10350 KB, uploaded 3 May 2018]


Droplet-based micromixers are essential units in many microfluidic devices for widespread applications, such as diagnostics and synthesis. The mixers can be either passive or active. When compared to active methods, the passive mixer is widely used because it does not require extra energy input apart from the pump drive. In recent years, several passive droplet-based mixers were developed, where mixing was characterized by both experiments and simulation. A unified physical understanding of both experimental processes and simulation models is beneficial for effectively developing new and efficient mixing techniques. This review covers the state-of-the-art passive droplet-based micromixers in microfluidics, which mainly focuses on three aspects: (1) Mixing parameters and analysis method; (2) Typical mixing element designs and the mixing characters in experiments; and, (3) Comprehensive introduction of numerical models used in microfluidic flow and diffusion. View Full-Text
Keywords: passive mixing; microdroplets; multiphase; simulation model passive mixing; microdroplets; multiphase; simulation model

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Chen, C.; Zhao, Y.; Wang, J.; Zhu, P.; Tian, Y.; Xu, M.; Wang, L.; Huang, X. Passive Mixing inside Microdroplets. Micromachines 2018, 9, 160.

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