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Micromachines 2018, 9(11), 583; https://doi.org/10.3390/mi9110583

A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording

1
Rehabilitation Research and Development, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA
2
Advanced Platform Technology Center, Cleveland, OH 44106, USA
3
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
*
Author to whom correspondence should be addressed.
Received: 14 September 2018 / Revised: 19 October 2018 / Accepted: 2 November 2018 / Published: 8 November 2018
(This article belongs to the Special Issue Neural Microelectrodes: Design and Applications)
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Abstract

Mechanical, materials, and biological causes of intracortical probe failure have hampered their utility in basic science and clinical applications. By anticipating causes of failure, we can design a system that will prevent the known causes of failure. The neural probe design was centered around a bio-inspired, mechanically-softening polymer nanocomposite. The polymer nanocomposite was functionalized with recording microelectrodes using a microfabrication process designed for chemical and thermal process compatibility. A custom package based upon a ribbon cable, printed circuit board, and a 3D-printed housing was designed to enable connection to external electronics. Probes were implanted into the primary motor cortex of Sprague-Dawley rats for 16 weeks, during which regular recording and electrochemical impedance spectroscopy measurement sessions took place. The implanted mechanically-softening probes had stable electrochemical impedance spectra across the 16 weeks and single units were recorded out to 16 weeks. The demonstration of chronic neural recording with the mechanically-softening probe suggests that probe architecture, custom package, and general design strategy are appropriate for long-term studies in rodents. View Full-Text
Keywords: neural probe; intracortical; microelectrodes; bio-inspired; polymer nanocomposite; cellulose nanocrystals; photolithography; Parylene C neural probe; intracortical; microelectrodes; bio-inspired; polymer nanocomposite; cellulose nanocrystals; photolithography; Parylene C
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hess-Dunning, A.; Tyler, D.J. A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording. Micromachines 2018, 9, 583.

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