Next Article in Journal
A Modified Cooperative A* Algorithm for the Simultaneous Motion of Multiple Microparts on a “Smart Platform” with Electrostatic Fields
Next Article in Special Issue
Biocatalysis by Transglutaminases: A Review of Biotechnological Applications
Previous Article in Journal
AlGaN/GaN High Electron Mobility Transistors on Semi-Insulating Ammono-GaN Substrates with Regrown Ohmic Contacts
Previous Article in Special Issue
Self-Assembled Mucin-Containing Microcarriers via Hard Templating on CaCO3 Crystals
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle

Internal Structure of Matrix-Type Multilayer Capsules Templated on Porous Vaterite CaCO3 Crystals as Probed by Staining with a Fluorescence Dye

1
Robert Schuman University Institute of Technology (IUT Robert Schuman), University of Strasbourg, 72 Route Du Rhin, 67411 Illkirch CEDEX, France
2
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
3
Department of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, 119991 Moscow, Russia
4
Department Cellular Biotechnology & Biochips, Branch Bioanalytics and Bioprocesses (Fraunhofer IZI-BB), Fraunhofer Institute for Cell Therapy and Immunology, Am Mühlenberg 13, 14476 Potsdam-Golm, Germany
*
Author to whom correspondence should be addressed.
Micromachines 2018, 9(11), 547; https://doi.org/10.3390/mi9110547
Received: 28 September 2018 / Revised: 19 October 2018 / Accepted: 23 October 2018 / Published: 25 October 2018
(This article belongs to the Special Issue Self-Assembly of Polymers)
  |  
PDF [3653 KB, uploaded 25 October 2018]
  |  

Abstract

Multilayer capsules templated on decomposable vaterite CaCO3 crystals are widely used as vehicles for drug delivery. The capsule represents typically not a hollow but matrix-like structure due to polymer diffusion into the porous crystals during multilayer deposition. The capsule formation mechanism is not well-studied but its understanding is crucial to tune capsule structure for a proper drug release performance. This study proposes new approach to noninvasively probe and adjust internal capsule structure. Polymer capsules made of poly(styrene-sulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDAD) have been stained with fluorescence dye rhodamine 6G. Physical-chemical aspects of intermolecular interactions required to validate the approach and adjust capsule structure are addressed. The capsules consist of a defined shell (typically 0.5–2 µm) and an internal matrix of PSS-PDAD complex (typically 10–40% of a total capsule volume). An increase of ionic strength and polymer deposition time leads to the thickening of the capsule shell and formation of a denser internal matrix, respectively. This is explained by effects of a polymer conformation and limitations in polymer diffusion through the crystal pores. We believe that the design of the capsules with desired internal structure will allow achieving effective encapsulation and controlled/programmed release of bioactives for advanced drug delivery applications. View Full-Text
Keywords: layer-by-layer; self-assembly; mesoporous; calcium carbonate; fluorescence layer-by-layer; self-assembly; mesoporous; calcium carbonate; fluorescence
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Jeannot, L.; Bell, M.; Ashwell, R.; Volodkin, D.; Vikulina, A.S. Internal Structure of Matrix-Type Multilayer Capsules Templated on Porous Vaterite CaCO3 Crystals as Probed by Staining with a Fluorescence Dye. Micromachines 2018, 9, 547.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top