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A New Concept of a Drug Delivery System with Improved Precision and Patient Safety Features

Design of Microsystems, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
Author to whom correspondence should be addressed.
Micromachines 2015, 6(1), 80-95;
Received: 4 August 2014 / Accepted: 5 December 2014 / Published: 24 December 2014
(This article belongs to the Special Issue Micropumps: Design, Fabrication and Applications)
PDF [1848 KB, uploaded 24 December 2014]


This paper presents a novel dosing concept for drug delivery based on a peristaltic piezo-electrically actuated micro membrane pump. The design of the silicon micropump itself is straight-forward, using two piezoelectrically actuated membrane valves as inlet and outlet, and a pump chamber with a piezoelectrically actuated pump membrane in-between. To achieve a precise dosing, this micropump is used to fill a metering unit placed at its outlet. In the final design this metering unit will be made from a piezoelectrically actuated inlet valve, a storage chamber with an elastic cover membrane and a piezoelectrically actuated outlet valve, which are connected in series. During a dosing cycle the metering unit is used to adjust the drug volume to be dispensed before delivery and to control the actually dispensed volume. To simulate the new drug delivery concept, a lumped parameter model has been developed to find the decisive design parameters. With the knowledge taken from the model a drug delivery system is designed that includes a silicon micro pump and, in a first step, a silicon chip with the storage chamber and two commercial microvalves as a metering unit. The lumped parameter model is capable to simulate the maximum flow, the frequency response created by the micropump, and also the delivered volume of the drug delivery system. View Full-Text
Keywords: drug delivery system; lumped parameter model; micropump drug delivery system; lumped parameter model; micropump

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Thoma, F.; Goldschmidtböing, F.; Woias, P. A New Concept of a Drug Delivery System with Improved Precision and Patient Safety Features. Micromachines 2015, 6, 80-95.

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