A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis

Ben Halima, Hamdi; Zine, Nadia; Bausells, Joan; Jaffrezic-Renault, Nicole; Errachid, Abdelhamid

doi:10.3390/mi13122235

Open AccessArticle

A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis

by

Hamdi Ben Halima

^1,*

,

Nadia Zine

¹,

Joan Bausells

²

,

Nicole Jaffrezic-Renault

^1,*

and

Abdelhamid Errachid

¹

Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Lyon, France

²

Institute of Microelectronics of Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193 Barcelona, Spain

^*

Authors to whom correspondence should be addressed.

Micromachines 2022, 13(12), 2235; https://doi.org/10.3390/mi13122235

Submission received: 29 November 2022 / Revised: 12 December 2022 / Accepted: 14 December 2022 / Published: 16 December 2022

(This article belongs to the Special Issue Biosensors for Diagnostic and Detection Applications)

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Abstract

Assessing cortisol levels in human bodies has become essential to diagnose heart failure (HF). In this work, we propose a salivary cortisol detection strategy as part of an easily integrable lab-on-a-chip for detection of HF biomarkers. Our developed capacitive immunosensor based on hafnium oxide (HfO₂)/silicon structure showed good linearity between increasing cortisol concentration and the charge-transfer resistance/capacitance. Moreover, the developed biosensor was demonstrated to be highly selective toward cortisol compared to other HF biomarkers such as tumor necrosis factor (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP). The precision of our developed biosensor was evaluated, and the difference between the determined cortisol concentration in saliva and its expected one is <18%.

Keywords: heart failure; cortisol; electrochemical impedance spectroscopy; capacitance; hafnium oxide

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MDPI and ACS Style

Ben Halima, H.; Zine, N.; Bausells, J.; Jaffrezic-Renault, N.; Errachid, A. A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis. Micromachines 2022, 13, 2235. https://doi.org/10.3390/mi13122235

AMA Style

Ben Halima H, Zine N, Bausells J, Jaffrezic-Renault N, Errachid A. A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis. Micromachines. 2022; 13(12):2235. https://doi.org/10.3390/mi13122235

Chicago/Turabian Style

Ben Halima, Hamdi, Nadia Zine, Joan Bausells, Nicole Jaffrezic-Renault, and Abdelhamid Errachid. 2022. "A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis" Micromachines 13, no. 12: 2235. https://doi.org/10.3390/mi13122235

APA Style

Ben Halima, H., Zine, N., Bausells, J., Jaffrezic-Renault, N., & Errachid, A. (2022). A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis. Micromachines, 13(12), 2235. https://doi.org/10.3390/mi13122235

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A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis

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