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Article

3D-Printed Micro-Tweezers with a Compliant Mechanism Designed Using Topology Optimization

1
Graduate School of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan
2
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan
3
Department of Strategic Studies, Institute of Engineering Innovation, School of Engineering, the University of Tokyo, 2-11-16 Yayoi, Bunkyo–ku, Tokyo 113-8656, Japan
4
Department of Mechanical Engineering and Science, Kyoto University, C3 Kyotodaigaku-katsura, Nishikyo-ku, Kyoto, Kyoto 615-8540, Japan
5
Kanagawa Institute of Industrial Science and Technology (KISTEC), 3-2-1 Sakado Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Takahiro Namazu, Takashi Tokumasu, Masahiro Motosuke and Sumito Nagasawa
Micromachines 2021, 12(5), 579; https://doi.org/10.3390/mi12050579
Received: 27 April 2021 / Revised: 17 May 2021 / Accepted: 18 May 2021 / Published: 19 May 2021
The development of handling technology for microscopic biological samples such as cells and spheroids has been required for the advancement of regenerative medicine and tissue engineering. In this study, we developed micro-tweezers with a compliant mechanism to manipulate organoids. The proposed method combines high-resolution microstereolithography that uses a blue laser and topology optimization for shape optimization of micro-tweezers. An actuation system was constructed using a linear motor stage with a force control system to operate the micro-tweezers. The deformation of the topology-optimized micro-tweezers was examined analytically and experimentally. The results verified that the displacement of the tweezer tip was proportional to the applied load; furthermore, the displacement was sufficient to grasp biological samples with an approximate diameter of several hundred micrometers. We experimentally demonstrated the manipulation of an organoid with a diameter of approximately 360 µm using the proposed micro-tweezers. Thus, combining microstereolithography and topology optimization to fabricate micro-tweezers can be potentially used in modifying tools capable of handling various biological samples. View Full-Text
Keywords: topology optimization; 3D printing; microstereolithography; compliant mechanism; micro-manipulator; micro-tweezers topology optimization; 3D printing; microstereolithography; compliant mechanism; micro-manipulator; micro-tweezers
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MDPI and ACS Style

Moritoki, Y.; Furukawa, T.; Sun, J.; Yokoyama, M.; Shimono, T.; Yamada, T.; Nishiwaki, S.; Kageyama, T.; Fukuda, J.; Mukai, M.; Maruo, S. 3D-Printed Micro-Tweezers with a Compliant Mechanism Designed Using Topology Optimization. Micromachines 2021, 12, 579. https://doi.org/10.3390/mi12050579

AMA Style

Moritoki Y, Furukawa T, Sun J, Yokoyama M, Shimono T, Yamada T, Nishiwaki S, Kageyama T, Fukuda J, Mukai M, Maruo S. 3D-Printed Micro-Tweezers with a Compliant Mechanism Designed Using Topology Optimization. Micromachines. 2021; 12(5):579. https://doi.org/10.3390/mi12050579

Chicago/Turabian Style

Moritoki, Yukihito, Taichi Furukawa, Jinyi Sun, Minoru Yokoyama, Tomoyuki Shimono, Takayuki Yamada, Shinji Nishiwaki, Tatsuto Kageyama, Junji Fukuda, Masaru Mukai, and Shoji Maruo. 2021. "3D-Printed Micro-Tweezers with a Compliant Mechanism Designed Using Topology Optimization" Micromachines 12, no. 5: 579. https://doi.org/10.3390/mi12050579

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