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Article

Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery

1
Intelligent Robot Laboratory, Tianjin University of Technology, Tianjin 300380, China
2
Tianjin Key Laboratory for Control Theory & Application in Complicated Systems and Tianjin International Joint Research and Development Center, Tianjin University of Technology, Tianjin 300380, China
3
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China
4
Department of Intelligent Mechanical Systems Engineering, Kagawa University, Takamatsu 761-0396, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Beelee Chua and David C. K. Ng
Micromachines 2021, 12(10), 1210; https://doi.org/10.3390/mi12101210
Received: 12 September 2021 / Revised: 30 September 2021 / Accepted: 30 September 2021 / Published: 3 October 2021
Given that the current microrobot cannot achieve fixed-point and quantitative drug application in the gastrointestinal (GI) tract, a targeted drug delivery microrobot is proposed, and its principle and characteristics are studied. Through the control of an external magnetic field, it can actively move to the affected area to realize the targeted drug delivery function. The microrobot has a cam structure connected with a radially magnetized permanent magnet, which can realize two movement modes: movement and targeted drug delivery. Firstly, the magnetic actuated capsule microrobotic system (MACMS) is analyzed. Secondly, the dynamic model and quantitative drug delivery model of the targeted drug delivery microrobot driven by the spiral jet structure are established, and the motion characteristics of the targeted drug delivery microrobot are simulated and analyzed by the method of Computational Fluid Dynamics (CFD). Finally, the whole process of the targeted drug delivery task of the microrobot is simulated. The results show that the targeted drug delivery microrobot can realize basic movements such as forward, backward, fixed-point parking and drug delivery through external magnetic field control, which lays the foundation for gastrointestinal diagnosis and treatment. View Full-Text
Keywords: targeted drug delivery microrobot; cam structure; magnetic actuated capsule microrobotic system (MACMS); Computational Fluid Dynamics (CFD) targeted drug delivery microrobot; cam structure; magnetic actuated capsule microrobotic system (MACMS); Computational Fluid Dynamics (CFD)
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MDPI and ACS Style

Cai, Z.; Fu, Q.; Zhang, S.; Fan, C.; Zhang, X.; Guo, J.; Guo, S. Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery. Micromachines 2021, 12, 1210. https://doi.org/10.3390/mi12101210

AMA Style

Cai Z, Fu Q, Zhang S, Fan C, Zhang X, Guo J, Guo S. Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery. Micromachines. 2021; 12(10):1210. https://doi.org/10.3390/mi12101210

Chicago/Turabian Style

Cai, Zhuocong, Qiang Fu, Songyuan Zhang, Chunliu Fan, Xi Zhang, Jian Guo, and Shuxiang Guo. 2021. "Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery" Micromachines 12, no. 10: 1210. https://doi.org/10.3390/mi12101210

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