Next Article in Journal
Process Optimization of Via Plug Multilevel Interconnections in CMOS Logic Devices
Next Article in Special Issue
The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering
Previous Article in Journal
Flow Characteristics of the Entrance Region with Roughness Effect within Rectangular Microchannels
Previous Article in Special Issue
Advanced Polymers for Three-Dimensional (3D) Organ Bioprinting
Open AccessArticle

3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis

by 1 and 1,2,*
1
Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
2
Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(1), 31; https://doi.org/10.3390/mi11010031
Received: 22 November 2019 / Revised: 19 December 2019 / Accepted: 21 December 2019 / Published: 25 December 2019
(This article belongs to the Special Issue 3D Printing for Tissue Engineering and Regenerative Medicine)
There is a growing interest in developing 3D porous scaffolds with tunable architectures for bone tissue engineering. Surface topography has been shown to control stem cell behavior including differentiation. In this study, we printed 3D porous scaffolds with wavy or linear patterns to investigate the effect of wavy scaffold architecture on human mesenchymal stem cell (hMSC) osteogenesis. Five distinct wavy scaffolds were designed using sinusoidal waveforms with varying wavelengths and amplitudes, and orthogonal scaffolds were designed using linear patterns. We found that hMSCs attached to wavy patterns, spread by taking the shape of the curvatures presented by the wavy patterns, exhibited an elongated shape and mature focal adhesion points, and differentiated into the osteogenic lineage. When compared to orthogonal scaffolds, hMSCs on wavy scaffolds showed significantly enhanced osteogenesis, indicated by higher calcium deposition, alkaline phosphatase activity, and osteocalcin staining. This study aids in the development of 3D scaffolds with novel architectures to direct stem osteogenesis for bone tissue engineering. View Full-Text
Keywords: biomaterials; additive manufacturing; stem cells; tissue engineering; bone regeneration biomaterials; additive manufacturing; stem cells; tissue engineering; bone regeneration
Show Figures

Figure 1

MDPI and ACS Style

Ji, S.; Guvendiren, M. 3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis. Micromachines 2020, 11, 31. https://doi.org/10.3390/mi11010031

AMA Style

Ji S, Guvendiren M. 3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis. Micromachines. 2020; 11(1):31. https://doi.org/10.3390/mi11010031

Chicago/Turabian Style

Ji, Shen; Guvendiren, Murat. 2020. "3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis" Micromachines 11, no. 1: 31. https://doi.org/10.3390/mi11010031

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop